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Cortexin®
49 Reviews
Chemical name | Cortexin |
Form: | 10 vials of 5 mg / 10 vials of 10 mg |
Form description: | Lyophilized powder or porous mass of white or white-yellowish color |
Active ingredient: | Cortexin® (complex of water-soluble polypeptide fractions): 5 mg in a 3 ml vial, and 10 mg in a 5 ml vial |
Excipients: | Glycine (stabilizer) – 6 mg in a 3 ml vial and 12 mg in a 5 ml vial. |
СAS Number: | 83270-84-2 |
ATC code: | N06BX |
Pharmacological action: | Neuroprotective, nootropic, antioxidant, tissue-specific |
Shelf life: | 3 years. Do not use it beyond the expiration date printed on the package. |
Storage conditions: | Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep in a safe place out of reach of children. |
Terms of release: | Over-the-counter |
Manufacturer: | Gerofarm, Russia |
What is Cortexin?
Cortexin is a mixture of neuropeptide fractions, amino acids, vitamins, and minerals, all of which have a mild positive effect on the brain. Cortexin is based on neuropeptides and amino acids that are extracted mostly from young horned cattle cerebral cortex by acetic acid extraction.
What is Cortexin Used for?
Cortexin is used to correct impaired molecular and cellular processes, and according to the manufacturer, can be applied for the following conditions:
- cerebral circulation disorders;
- encephalopathy of various genesis;
- acute and chronic encephalitis and encephalomyelitis;
- epilepsy;
- traumatic brain injury and its consequences;
- asthenia;
- infantile cerebral palsy;
- psychomotor and speech retardation in children;
- cognitive disorders (dysfunction of memory and ideation);
- reduced learning ability.
More detailed information about the studies on the application can be found in the Research tab.
What are the Benefits and Effects of Cortexin?
Cortexin has the following effects:
Nootropic effect
It improves higher cerebral functions, processes of learning and memory, concentration, attention, and tolerance to mental and physical stress.
Neuroprotective effect
It protects neurons against different endogenous neurotoxic factors (glutamate, calcium ions, and free radicals) and reduces the toxic impact of psychotropic agents.
Antioxidant effect
It inhibits lipid peroxidation and increases the survival of neurons under oxidative stress and hypoxia.
Tissue-specific effect
It activates the metabolism of neurons of the central and peripheral nervous system as well as reparative processes; also, it promotes stimulation of cortical function and general improvement of the nervous system.
Is Cortexin Safe to Take?
Cortexin is not recommended for pregnant and lactating women due to the lack of data and people with individual intolerance.
FAQ:
What is Cortexin Composition?
Amino acids: Aspartic acid – 446 nmol/mg; Glycine – 298 nmol/mg; Threonine – 212 nmol/mg; Serine – 268 nmol/mg; Glutamic acid – 581 nmol/mg; Proline – 187 nmol/mg; Alanine – 246 nmol/mg; Isoleucine – 356 nmol/mg; Tyrosine – 109 nmol/mg; Phenylalanine – 162 nmol/mg; Histidine – 116 nmol/mg; Lysine – 253 nmol/mg; Arginine and other amino acids – 202 nmol/mg. Vitamins: Lysine – 253 nmol/mg; Thiamine (Vitamin B1) – 0.08 mcg/10mg; Riboflavin (Vitamin B2) – 0.03 mcg/10 mg; Niacin (Vitamin B3, Vitamin PP) – 0.05 mcg/10 mg; Retinol (Vitamin A) – 0.011 mcg/10mg; Alfa-tokoferol (vitamin E) – 0.007 mcg/10mg. Minerals: (Cu) – 0.2129 mcg/10 mg; (Fe) – 2.26 mcg/10 mg; (Ca) – 22.93 mcg/10 mg; (Mg) – 8.5 mcg/10 mg; (K) – 19.83 mcg/10 mg; (Na) – 643.2 mcg/10 mg; (S) – 152.65 mcg/10 mg; (P) – 91.95 mcg/10 mg; (Zn) – 4.73 mcg/10 mg; (Mb) – 0.0203 mcg/10 mg; (Co) – 0.0044 mcg/10 mg; (Mn) – 0.0061 mcg/10 mg; (Se) – 0.0745 mcg/10 mg; (Al) – 0.3104 mcg/10 mg; (Li) – 0,0340 mcg/10 mg.
Where Can I Order Cortexin Online?
You can order Cortexin online from different vendors. CosmicNootropic offers Cortexin in packs of 10x5mg and 10x10mg vials with worldwide shipping! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product. You can order Cortexin and get it delivered to the USA, Europe, the UK, Asia, and many other destinations via CosmicNootropic.
How Should Cortexin Be Prepared and Administered Safely?
To safely prepare and administer Cortexin: - Dissolve the contents of one vial in 1–2 ml of either 0.5% procaine (Novocain) solution, sterile water for injection, or 0.9% sodium chloride solution. - Use sterile equipment – always use sterile needles and wear sterile plastic gloves. - Sterilize the injection site before administering. - Administer the injection immediately after preparing the solution. - Inject slowly into relaxed muscles (intramuscularly).
What Forms and Dosages Does Cortexin Come In?
Cortexin comes in injection form only: 10 mg – for adults, and 5 mg – for children.
When Should Cortexin Be Taken?
Cortexin should be taken in the first part of the day, before 3 p.m.
What is the Dosage of Cortexin?
Cortexin is typically dosed based on the specific indication. The standard regimen for adults is 10 mg per day, administered via intramuscular injection once daily for 10 days. For pediatric dosing, please refer to the official instructions. If needed, the treatment course can be repeated after 3–6 months of discontinuation. Always consult a healthcare professional to c
What are the Side Effects of Cortexin?
Cortexin is generally well-tolerated when used as directed. However, side effects may include individual hypersensitivity or allergic reactions to its components. It’s important to monitor your body’s response, especially during the first administration. If you notice any adverse effects, consult your doctor immediately.
For more information on Cortexin dosages and side effects, please refer to the translated official drug sheets linked below.
Cortexin Official Instruction
- Coulter et al (1993) Identification of cortexin: a novel, neuron-specific, 82-residue membrane protein enriched in rodent cerebral cortex.
- Khavinson et al (1999) Cortexin effectiveness in circulatory encephalopathy.
- Shabanov et al (2007) Comparison of behavioral effects of cortexin and other brain peptides injected into brain ventricles.
- Shabanov et al (2007) Comparative study of behavioral effects of cortexin and other brain peptides upon intraventricular and intraperitoneal administration in rats.
- Nurguzhaev et al (2009) Use of cortexin in the early rehabilitation period of ischemic stroke of moderate severity.
- B Gafurov, Sh Gafurov (2010) Cortexin in the complex treatment of post stroke epilepsy.
- A Solov’ev, T Elistratova (2010) Effectiveness of cortexin in the complex treatment of patients with chronic alcohol encephalopathy and polyneuropathy.
- Mendzheritsky et al (2015) Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia.
- Belova et al (2016) Efficacy of cortexin in acute and recovery periodes of hemispheric ischemic stroke.
- Yakovlev et al (2017) Peptide drug cortexin inhibits brain caspase-8.
- A Yakovlev, N. Gulyaeva (2017) Molecular partners of Cortexin in the brain.
- Zukov et al (2018) Results of a multicenter study on the efficacy of cortexin in treatment of cognitive dysfunction in children.
- N Gulyaeva (2018) Molecular mechanisms of brain peptide-containing drugs: cortexin.
- A Fedin (2018) The efficacy of cortexin and memantinol (memantine) in the treatment of cognitive impairment in patients with chronic cerebral ischemia.
- Belova et al (2018) Efficacy of Korteksin in acute period of hemispheric ischemic stroke.
- Fedin et al (2018) Dose-dependent effects of cortexin in chronic cerebral ischemia (results of a multicenter randomized controlled study).
- Gulyaeva (2019) Molecular Mechanisms of the Actions of Brain Peptide-Containing Drugs: Cortexin.
- Mashin et al (2019) Evaluation of the efficacy and safety of application of the drug cortexin in the complex rehabilitation of verticalization in patients with ischemic stroke in the acute period.
- Putilina et al (2022) Determination of the prevalence of postcovid syndrome and assessment of the effectiveness of the drug Cortexin in the treatment of neurological disorders in patients with postcovid syndrome. Results of the multicenter clinical and epidemiological observational program CORTEX.
4.5
Based on 49 Reviews
(40)
(3)
(1)
(0)
(5)
02/15/2025
Michael A.
Verified BuyerUS
Best selection best service
Always a pleasure ordering from CN. Keep up the fantastic work CN. Placing another order soon.
01/01/1970
CosmicNootropic
Dear Michael, thank you so much for your kind words! We're thrilled to hear that you had a great experience with our selection and service. We truly appreciate your support and look forward to serving you again soon.
01/21/2025
Mike
Verified BuyerUS
Good Product, If You Take Enough
I had accidentally gotten the 5mg vials, which is the children’s dose. Once I started taking two of them I got much better mental clarity and focus.
01/01/1970
CosmicNootropic
Dear Mike, thank you for your feedback! We’re glad to hear that you’re experiencing better mental clarity and focus. It’s always important to find the right dosage, and we appreciate you sharing your experience with us. If you have any questions or need further assistance, feel free to reach out!
11/20/2024
Josh
Verified BuyerUS
I finally can win Arguments with my Wife!
My personal experience may not be the same as your\'s. I have ADHD, short term memory issues, and some brain fog: I took a lot of time researching between Cortexin and Cerebralysin. I went with Cortexin because I saw a video from one of the guys that manufactures it. He said Cortexin is a safer and more modern answer to Cerebralysin. Also it\'s freeze dried powder that you mix when you are ready to use. You can mix it with several different solvents. I didn\'t want to take any chances so I got a box of 0.9% Sodium Chloride one time use ampules. So when I mix it there is no filler, no preservatives no nothing, just saline and the medicine. Cerebralysin does contain a preservative, not a bad thing, just I prefer the least amount of chemicals when it comes to IM injections. Lastly on he deciding factor Cerebralysin requires upwards of 5ml injections which anything over 2.5ml can cause a bit of pain. My Experience with this meds has been very nice. For injecting I use a 1inch 30g needle. It is nearly painless. There is a very slight bit of soreness that occurs for about 1 hour after the injection but not that bad. A flu shot is way worse. Medicine is very smooth. It also mixes incredibly well. You don\'t have to shake it and I recommend you not to so you don\'t damage any amino chains. Now the part you all are probably reading this for...What did it do to me? Well for the first 2 days I noticed really nothing. The Third day/injection I went to work as normal and noticed I was thinking quicker. Able to perform the complex operations of my job easier, and my short term memory which is shot, was actually working! Brain fog was gone. It\'s interesting how this works. Since it\'s really working on your brain, you sorta just settle in to doing everything better without really noticing at first. I started noticing improvements when I remembered where I parked my car at work, which is a struggle, then I realized I could easily remember numbers and directions, then I noticed I could recall task I needed to do and was able to prioritize them which is the first time I have been really successful at that. I don\'t really get an energy boost or anything from it, but I did notice I wake up quicker. I normally have very high anxiety and starting on Day 4 I noticed that wasn\'t really a thing anymore. I no longer get anxiety when I think of task that I need to do for the day. Cortexin really does help improve cognition and enables me to use my brain (thinking skills) much more efficiently. I also find I can think MUCH quicker and more cleverly. I am able to defend myself and when verbal debates/arguments quite easily. I feel like my IQ has improved by 100% LOL. I don\'t know how long this stuff will be available in the states due to issues happening right now so I am thinking of picking up another box and storing it a while just in case it becomes unavailable to ship to the US, as the official instructions state the effects can decline after 3-6 months so running a course twice in a year might be best. I still have 5 days left on my 10 day course and I am already getting all these benefits. Mentally I feel as sharp as I did 30 years ago. Absolutely incredible and since im having such good results I am thinking I may try Cerebralysin maybe just 10 days worth right after finishing this cortex course for a 20 day treatment plan. I\'m going to sleep on that one tonight. Anyway I hope this review helps others on the fence out. The hardest part of it is doing the first injection. After that it\'s a breeze. That 1 inch needle was a little scary for me at first but choosing my upper thy or buttocks has proven to be pretty much painless as far as that goes.
01/01/1970
CosmicNootropic
Hi Josh! Thank you for sharing such a detailed review and your incredible experience with Cortexin! It’s amazing to hear how it’s helped improve your cognition, memory, and even reduced anxiety. Your insights about the preparation and injection process are very helpful for others considering this option. We’re thrilled it has had such a positive impact, and we appreciate you taking the time to share your journey. Wishing you continued success on your cognitive health journey!
11/11/2024
Heather W.
Verified BuyerUS
Love this!
Highly recommend for brain clarity and overall focus. Also noticeable stress reduction.
01/01/1970
CosmicNootropic
Hi Heather! Thank you for the wonderful review! We're thrilled to hear that our product is helping with clarity, focus, and stress reduction. Your recommendation means a lot to us, and we’re glad it’s making a positive difference for you. Thanks for choosing us!
09/22/2024
Brandon
Verified BuyerUS
Cortexin
Has anyone tried injecting this IV instead of IM? I am doing this and have great results I also adminiter IV with Cerebrolysin and it\'s the best result.
01/01/1970
CosmicNootropic
Thanks for sharing your experience with Cortexin and Cerebrolysin! It's great to hear that you’re achieving such positive results with IV administration. However, it is important to note that according to the official instructions, Cortexin is meant for IM administration only. Everyone's body responds differently, so it’s always interesting to hear about different methods. Just a reminder to consult with a healthcare professional when experimenting with any treatments. If you have any more insights or questions, feel free to share!
09/18/2024
Ivan W.
Verified BuyerUS
Helps reverse methamphetamine brain damage
Was stupid and abused methamphetamine that my parents BOUGHT ME. Got severe brain damage visible on a PET scan. Also pill mill doctors overprescribing me Adderall saying it'll help me (it did nothing good) Reduced my persistent anxiety from the damage and more motivation. Very expensive. It was like about $6000 to cause the damage it'll take half that amount to reverse repair it.
01/01/1970
CosmicNootropic
Hi Ivan! Thank you for sharing your experience. It's clear that you've been through a lot, and we appreciate your openness. It’s important to mention that individual experiences can vary greatly, and what works for one person may not work for another. We always recommend consulting with a qualified healthcare professional before making any decisions about treatment or medication. Your journey is unique, and it's vital to seek personalized advice tailored to your needs. Wishing you the best on your path to recovery.
09/10/2024
Brandy P.
Verified BuyerUS
Amazing
My husband and I both love this product. We stack it with Cerebro and I swear we have super powers, lol. Super sharp recall , fog lifted, feel amazing.
01/01/1970
CosmicNootropic
Hi Brandy! Thank you so much for your enthusiastic review! We're thrilled to hear that Cortexin and Cerebrolysin are working wonders for you and your husband. It's fantastic to know that this product worked for you :)
08/13/2024
Kevin
Verified BuyerFR
It works long after
It doesn\'t give me super brain, but it gives me an appreciable cognitive boost, especially for my memory. And best of all, the effect lasts a long time after the 10 dose course ends. For 2 months after I did my first course, I never forgot where I parked! It\'s my favorite nootropic.
01/01/1970
CosmicNootropic
Hi Kevin! Thank you so much for your feedback! We’re thrilled to hear that our nootropic has had a positive impact on your memory and that you’ve experienced lasting benefits. It’s fantastic to know it’s become your favorite!
08/06/2024
Lina R.
Verified BuyerUS
Reliable brain support
I found both cerebrolysin and cortexin being reliably helpful for my brain function recovering from mold toxicity, lyme, other toxicities that has left me foggy, costant headaches, reduced executive functions, etc These two, I can say with certainty, have been vital in supporting my mind in finding it's way back to myself. Thank you for making this easily available and your awesome customer service with a prompt responses to my enquiries.
01/01/1970
CosmicNootropic
Hi Lina! Thank you so much for your thoughtful review! We’re delighted to hear that both Cerebrolysin and Cortexin have been instrumental in supporting your recovery. It’s incredibly rewarding to know our products and customer service have made a positive impact on your journey back to better health. If you have any questions or need further assistance, we’re always here to help. Wishing you continued progress and wellness!
07/28/2024
Jayc
Verified BuyerUS
For me Cortagen was more effective
I did a round of cortagen before this and it had a solid reduction effect on my palinopsia. It was super expensive so I decided to take cortexin because it was cheaper. Even though I took 4x as much cortexin than cortagen it almost didn\'t have any affect at all. I didn\'t know if that\'s because I reaped all the benefits from cortagen, if the cortexin was degraded in transport as it took a long time in transport, or if the cortagen is just that more potent.
01/01/1970
CosmicNootropic
Hi Jayc! Thank you for sharing your experience. We understand that cost considerations are important, and we’re sorry to hear that Cortexin didn’t meet your expectations. The effectiveness of the products can vary, and such factors as personal conditions and dosage can play a role.
07/28/2024
Jayc
Verified BuyerUS
For me Cortagen was more effective
I did a round of cortagen before this and it had a solid reduction effect on my palinopsia. It was super expensive so I decided to take cortexin because it was cheaper. Even though I took 4x as much cortexin than cortagen it almost didn\'t have any affect at all. I didn\'t know if that\'s because I reaped all the benefits from cortagen, if the cortexin was degraded in transport, or if the cortagen is just that more potent.
07/25/2024
Jessica H.
Verified BuyerUS
Helped husband with TBI symptoms
Definitely was able to start thinking more clearly and make better decisions. Cognitive function improved greatly. Mood and temper improved as well.
01/01/1970
CosmicNootropic
Hi Jessica! Thank you so much for sharing your experience! We're delighted to hear that our product could make such a positive impact on your husband's life!
07/06/2024
corey r.
Verified BuyerAU
Fantastic service
Great. Super helpful when I contacted with a shipping question.
01/01/1970
CosmicNootropic
Hi Corey! Thank you for your wonderful feedback! We're delighted to hear that you found our service fantastic and our team helpful. Ensuring a seamless experience, from inquiries to delivery, is our goal.
05/23/2024
Sanije B.
Verified BuyerDK
terrible
It was terrible. I have not recieved my shipment and not refund! The policies of refundment are just terrible.
01/01/1970
CosmicNootropic
Hi Sanije! We are so sorry to hear this, thank you for reaching out. We have emailed you to see what can be done in this situation.
01/04/2024
Kevin
Verified BuyerPK
Appreciable and lasting benefit
This is one of my top 3 nootropics. This stuff makes a noticeable difference in my focus and memory. And one 10-day course leaves a benefit that lasts a few weeks. After the first time I tried it, I never forgot where I parked for like 2 months. Normally that\'s always a problem for me. Of course it helps in other ways too besides parking.
01/01/1970
CosmicNootropic
Dear Kevin, we are happy to hear that you are satisfied with this product :) Thank you for leaving the review!
12/27/2023
Joshua
Verified BuyerUS
Excelente for Lyme Recovery
After 10 years of brain fog from Lyme disease I\'m finally seeing light at the end of the tunnel. I find that cortexin gives me more mental energy and clarity. I\'m suddenly remembering the words to songs I didn\'t know I knew lol. It is also helping with my anxiety. It seems to make my brain sharper than cerebrolisyn. In 6 months I would like to do another course of cortexin with cerebrolisyn.
12/22/2023
Joshua
Verified BuyerGreat Product
After 10 years of brain fog from Lyme disease I\'m finally seeing light at the end of the tunnel. I find that cortexin gives me more mental energy and clarity. I\'m suddenly remembering the words to songs I didn\'t know I knew lol. It is also helping with my anxiety. It seems to make my brain sharper than cerebrolisyn. In 6 months I would like to do another course of cortexin with cerebrolisyn.
01/01/1970
CosmicNootropic
Hi Joshua! Thank you for finding a moment to leave a review. We're beyond happy to know that this product helped you with such a serious issue.
12/20/2023
Joshua
Verified BuyerMore Mental Clarity than Cerebrolisyn
After 10 years of brain fog from Lyme disease I\'m finally seeing light at the end of the tunnel. I find that cortexin gives me more mental energy and clarity. I\'m suddenly remembering the words to songs I didn\'t know I knew lol. It is also helping with my anxiety. It seems to make my brain sharper than cerebrolisyn. In 6 months I would like to do another course of cortexin with cerebrolisyn.
12/05/2023
Jeff D.
Verified BuyerUS
Bait and switched me
It boggles my mind that I paid for 10 vials, and they gave me a tracking # that had no cortexin in it at all. It\'s super infuriating. Only now, 11 days after paying for it, am I seeing the banner running saying you\'re out of stock. This is beyond unacceptable! People count on these meds and your company, with our lives and health depending on it, and this is what you let happen? Forcing me to source it elsewhere.
01/01/1970
CosmicNootropic
Dear Jeff, We understand your frustration with the temporary delays in our warehouse and we deeply apologize. Now your order is on its way and will be delivered shortly. Please check your email.
12/05/2023
Jeff D.
Verified BuyerUS
Never got what I paid for!!!
Paid for 10 vials of cortexin and never got them!!
01/01/1970
CosmicNootropic
Dear Jeff, your order is on its way and will be delivered shortly. Please check your email.
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