Actovegin®
25 Reviews
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Description
Dosage
Research
Reviews
| Chemical name | Actovegin |
| Form: | 5 ampoules of 5 ml / 50 pills of 200 mg |
| Form description: | Clear yellowish solution for injection / Glassy greenish-yellow film-coated tablets of a round biconvex shape |
| Active substance: | Actovegin (deproteinized hemoderivative of calf blood) |
| Excipients (pills): | Magnesium stearate – 2.0 mg, talc – 3.0 mg, povidone-K 90 – 10.0 mg, microcrystalline cellulose – 135.0 mg.; Coating: gum acacia – 6.8 mg, glycolic mineral wax – 0.1 mg, hypromellose phthalate – 29.45 mg, diethyl phthalate – 11.8 mg, quinoline yellow colorant – 2.0 mg, macrogol-6000 – 2.95 mg, povidone-K 30 – 1.54 mg, sucrose – 52.3 mg, talc – 42.2 mg, titanium dioxide – 0.86 mg |
| Excipients (injections): | Water for injection |
| СAS Number: | 63748-11-8 |
| ATC code: | B06AB |
| Pharmacological action: | Tissue regeneration stimulator |
| Shelf life: | 3 years. Do not use it beyond the expiration date printed on the package. |
| Storage conditions: | Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep out of reach of children. |
| Terms of Release: | Over-the-counter |
| Manufacturer: | Takeda Pharmaceutical, Austria/Russia |
What is Actovegin?
Actovegin is a biologically active extract that enhances aerobic oxidation, absorption of glucose, and oxygen uptake in tissue. It is derived from the blood of young calves (under three months old) and undergoes an advanced ultrafiltration process to remove proteins and potentially harmful substances, including prions.
What is Actovegin Used For?
Actovegin may be used for the following applications:
- Malfunction of the blood circulation and trophic disorders of the brain;
- Impairment of peripheral blood circulation and associated diseases;
- Cognitive impairments such as dementia and post-stroke cognitive impairments;
- Diabetic neuropathy as part of complex therapy;
- Dermal transplants and acute and chronic wounds.
Actovegin has also been used by athletes who wanted to speed up the recovery process and enhance physical performance and stamina. It is also deemed a great option to treat various sports injuries. More detailed information about the studies on the application can be found in the Research tab.
What are the Benefits and Effects of Actovegin?
Actovegin provides three primary effects (according to the manufacturer):
Metabolic Effect
It increases the absorption and utilization of oxygen. It impacts positively on the utilization and transport of glucose, which leads to improved cellular metabolism and lowers lactate formation in case of ischemia.
Neuroprotective Effect
The neuroprotective effect is attributed to its ability to improve the regulation of apoptosis processes and inflammation in the central and peripheral nervous systems and repair single-chain DNA.
Microcirculatory Effect
The microcirculatory effect is due to an increase in the speed of capillary blood flow, a decrease in pericapillary space, a decrease in the myogenic tone of the precapillary arterioles and capillary sphincters, a decrease in the degree of blood flow with an improved circulation of blood in the capillary bed, as well as stimulation of endothelial nitric oxide synthase function, which influences the microcirculatory bed.
Is Actovegin Safe to Take?
Actovegin should be taken with precautions in case of hypersensitivity to this or analogous drugs and their excipients.
FAQ:
Can I Overdose on Actovegin?
No overdose cases have been reported with Actovegin. However, it is always recommended to follow the prescribed dosage and consult with a healthcare provider if you have concerns.
What is Actovegin Composition?
Actovegin is composed of various physiologically active ingredients, including: - Amino acids such as ornithine, leucine, alanine, glutamate, proline, glycine, taurine, and others; - Oligopeptides; - Lipids; - Oligosaccharides; - Nucleosides like adenosine and uridine; - Antioxidants; - Electrolytes including Na, Cl, K, Mg, Ca, F, Fe; - Microelements such as Cu, Si, Se, and Zn. Organic compounds make up 30% of the Actovegin extract.
Where Can I Order Actovegin Online?
You can order Actovegin online from different vendors. CosmicNootropic offers Actovegin in packs of 5x5ml ampoules and 50x200mg pills with worldwide shipping! Always research reputable sources before purchasing to ensure product quality. Actovegin is approved in 17 countries, including Russia, China, South Korea, Latvia, and others. You can order Actovegin with delivery to the USA, Europe, the UK, Asia, and many other regions through CosmicNootropic.
What Is the Origin of Actovegin?
The origin of Actovegin dates back to when Swiss shepherds observed that young calves healed injuries and regenerated tissue much faster than older calves. In 1957, Swiss scientists developed a highly purified extract from the blood of young calves, which evolved into the drug now known as Actovegin.
Is Actovegin Banned by WADA?
Actovegin caused a lot of discussion and speculation after it was used by several athletes at the Sydney Olympic Games and Tour de France in 2000. The drug was suspected to have doping effects.
However, the World Anti-Doping Agency (WADA) has not included Actovegin in its list of prohibited substances.
Some studies show that in order to induce considerable performance enhancement effects with Actovegin, one has to exceed the permitted injectable amount of 50 ml every 6 hours.
What is the Dosage of Actovegin?
Actovegin Pills
1-2 tablets 3 times per day before meals. Do not chew the tablet. Drink some water after the administration. The course duration is 4-6 weeks.
Actovegin Injections
Actovegin injections are typically administered by a healthcare professional. The exact dosage and method of administration depend on the condition being treated. Always follow your healthcare provider’s instructions regarding injection technique and frequency.
According to the manufacturer, the usual dosage of injections is 5-10 ml intramuscularly or intravenously 3-4 times a week.
In case of mild metabolic disturbances, the dose is 5 ml.
In case of severe metabolic disturbances, traumatic brain injury, and strokes, the recommended dose is 10 ml.
What are the Side Effects of Actovegin?
Actovegin may cause mild side effects, including allergic reactions, swelling at the injection site, or discomfort. If you experience any severe reactions or side effects, contact your healthcare provider immediately.
For more information on Actovegin dosages and side effects, please refer to the translated official drug sheets linked below.
Actovegin Pills Official Instruction
Actovegin Injections Official Instruction
- Baiandin et al. (1992) The effect of trental and actovegin on the organs of vision when administered into the end periorbital branches of the ophthalmic artery (experimental research)
- Ziegler et al. (2009) Treatment of symptomatic polyneuropathy with actovegin in type 2 diabetic patients
- Elmlinger et al. (2011) Neuroprotective and anti-oxidative effects of the hemodialysate actovegin on primary rat neurons in vitro
- Lee et al. (2011) Our experience on Actovegin, is it cutting edge?
- Machicao et al. (2012) Pleiotropic neuroprotective and metabolic effects of Actovegin’s mode of action
- Dieckmann et al. (2012) Treatment with Actovegin® improves sensory nerve function and pathology in streptozotocin-diabetic rats via mechanisms involving inhibition of PARP activation
- Guekht et al. (2013) A Randomised, Double-Blind, Placebo-Controlled Trial of Actovegin in Patients with Post-Stroke Cognitive Impairment: ARTEMIDA Study Design
- Melin et al. (2014) Treatment with Actovegin improves spatial learning and memory in rats following transient forebrain ischaemia
- A Fomin, D Pershakov (2015) Actovegin in treatment of critical limb ischemia
- Trofimova et al. (2016) An experimental in vitro study of antioxidant and antiradical properties of cytoflavin, vinpocetine, actovegin and ethylmethylhydroxypyridine succinate
- Søndergård et al. (2016) Actovegin, a non-prohibited drug increases oxidative capacity in human skeletal muscle
- Guekht et al. (2017) ARTEMIDA Trial (A Randomized Trial of Efficacy, 12 Months International Double-Blind Actovegin): A Randomized Controlled Trial to Assess the Efficacy of Actovegin in Poststroke Cognitive Impairment
- Y Vakhrushev, M Lyapina (2017) Correction of small bowel function as a new direction for treating patients with metabolic syndrome
- Ziegler et al. (2017) Predictors of response to treatment with actovegin for 6 months in patients with type 2 diabetes and symptomatic polyneuropathy
- Brock et al. (2018) Update on the Role of Actovegin in Musculoskeletal Medicine: A Review of the Past 10 Years
- Safarova et al. (2018) Methods of augmentation of antidepressant therapy (on the model of complex therapy with the inclusion of actovegin) in gerontopsychiatric hospital
- Firan et al. (2020) Current Synthesis and Systematic Review of Main Effects of Calf Blood Deproteinized Medicine (Actovegin®) in Ischemic Stroke
- Li et al. (2021) Neuroprotective Effects of Deproteinized Calf Serum in Ischemic Stroke
- La Fleur et al. (2022) Actovegin in the management of patients after ischemic stroke: A systematic review
5
Based on 25 Reviews
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03/19/2025
Lina R.
Verified Buyer
US
life energy supportive
I could definitely notice improvement in my overall life energy and vitality with this product and have reordered it multiple times.
01/01/1970
CosmicNootropic
Dear Lina, thank you for your review! We're so glad to hear that our product has helped improve your energy and vitality. We appreciate your continued trust and are happy to have you as a repeat customer!
02/15/2025
Marius M
Verified Buyer
DE
One of the best!
Firstly: I was told by some sources that Actovegin helps with joint pain. In my case it did NOT. I have no clue whether it\'s due to the nature of my injury or other factors. HOWEVER: I almost entirely forgot about the original purpose of using Actovegin because of the effects it did have. Nothing has boosted my mood and energy quite so clearly and intensely without increasing my heart rate or any other unwanted side effects. Working out feels amazing and I feel like I have the energy of a child again, but with the control of my adult mind. Even at work I\'m able to perform better due to Actovegin just preventing me from becoming tired after a long day. I dose it at 2.5ml every 2-3 days (depends on convenience and stock). Injections go super smoothly, barely feel anything afterwards and only for a short while. I genuinely wish I had a lifetime supply of these because this is just amazing. Works in 100% of use cases for me, and in combination with Caffeine and Nicotine I become unstoppable. I\'ll hope this stays available for as long as I live, because again: It\'s one of the best. Wholly recommended, 5 stars, 6 if I could.
01/01/1970
CosmicNootropic
Dear Marius, thank you for your thoughtful review! We're so glad to hear that Actovegin has boosted your energy, mood, and performance, even though it didn’t address your joint pain as expected. We truly appreciate your recommendation and are grateful for your support. It’s great to know that you're enjoying the benefits, and we’ll continue to provide you with high-quality products!
02/15/2025
Michael A.
Verified Buyer
US
Cognitive clarity enhancement
Fantastic product.
01/01/1970
CosmicNootropic
Dear Michael, thank you for your feedback! 🤗
01/31/2025
Alejandro A.
Verified Buyer
US
Absolute game changer
I cycle between Mildronat and Actovegin. So far, Actovegin has been one of the few that truly makes an impact on my physical and mental performance. No side effects, I\'m just very happy when I\'m in the Actovegin cycle given that I really feel the benefits and the fact that it\'s progressive, meaning I build on what I was able to enhance from previous cycles. Absolute must-have for serious biohackers.
01/01/1970
CosmicNootropic
Dear Alejandro, thank you for your detailed review! We're thrilled to hear Actovegin is making such a positive impact on your performance. It’s great to know you’re seeing both immediate and long-term benefits.
01/29/2025
Alejandro A.
Verified Buyer
US
Absolute game changer
I cycle between Mildronat and Actovegin, so far Actovegin has been one of the few that truly makes an impact in my physical and mental performance. No side effects, I\'m just very happy when I\'m in the Actovegin cycle given that I really feel the benefits and the fact that it\'s progressive, meaning I build on what I was able to enhance from previous cycles. Absolute must have for serious bio hackers.
01/01/1970
CosmicNootropic
Dear Alejandro, thank you for your amazing review! We're thrilled to hear that Actovegin has had such a positive impact on your performance!
01/27/2025
Lina R.
Verified Buyer
US
Beneficial
I have found actovegin tabs overall beneficial for overall energy and vitality while recovering from multiple toxicities and lyme disease. no noticeable side effects and have reordered several times already.
01/01/1970
CosmicNootropic
Dear Lina, thank you for your wonderful feedback! We're so glad to hear that Actovegin has been helpful in boosting your energy and vitality during your recovery.
11/18/2024
Asfaw T.
Verified Buyer
CH
Très bonne Produits
Très bien produit
01/01/1970
CosmicNootropic
Hi Asfaw! Merci! We're thrilled that you’re happy with our products. Looking forward to your next order :)
05/02/2024
Vincent C.
Verified Buyer
US
Great product
This product worked very fast and was highly effective. It was definitely worth getting
01/01/1970
CosmicNootropic
Hi Vincent! Thank you for leaving your review. We're happy to hear that this product worked for you!
04/02/2024
Violet E.
Verified Buyer
US
Really has Helped with an Unexpected Pleasant Surprise
I purchased this to help prevent cognitive aging. I'm really nervous about developing dementia that runs in my family. I've been struggling to focus and thinking clearly in my stressful job. This has helped lift the brain fog and reduce my stress level due to being about to think more clearly and resolve issues more quickly. I've also noticed the anti-inflammatory effect when injecting in my leg muscle that has sciatic pain. That's such an amazing unexpected effect! I'll definitely be purchasing this again!
01/01/1970
CosmicNootropic
Dear Violet, we are so happy to hear about your positive experience with this product! Thank you for sharing with us :)
01/22/2024
Nicholas C.
Verified Buyer
US
Great product for reducing inflammation
Bought it for my wife who has severe osteoarthritis in her hands and it has helped quite a bit
01/01/1970
CosmicNootropic
Dear Nicholas, thank you for your review, we are glad the product was helpful for your wife. We wish the health of your family!
01/09/2024
Eric A.
Verified Buyer
US
Actovegin - The Real Deal
I was skeptical but my cardio endurance went through the roof with Actovegin. I hope they restock soon!
01/01/1970
CosmicNootropic
Dear Eric, thank you for your feedback, we are glad you are satisfied with the product!
12/29/2023
Anil R.
Verified Buyer
MY
Actovegin - IV for anti-aging
Using it monthly and feeling GREAT - other people comment as well....hehe
01/01/1970
CosmicNootropic
Hi Anil! We are so happy to hear that you are satisfied with this product :) Thank you for leaving the review!
12/19/2023
jaime m.
Verified BuyerGreat quality
Since using actovegin my max heart rate has gone up 2 bpm and my treshold heart rate has gone 1 bpm. Since i started using it have a faster heart rate recovery and a lesser heart rate with the same effort as before.
01/01/1970
CosmicNootropic
Dear Jaime, thank you for sharing your experience, we really appreciate it!
09/23/2023
Anil R.
Verified Buyer
MY
Actovegin - IV for anti-aging
No adverse reaction.....taking it IV in saline solution with other vitamins....ALL GOOD....let me keep trying for a few more months, will re-order for wife's stock
01/01/1970
CosmicNootropic
Dear Anil, we're thrilled to know you liked the product. Please feel free to share your final thoughts on Actovegin after a course!
08/02/2023
Linda S.
Verified Buyer
US
NOT ME
I HAVE NO IDEA WHO YOU ARE OR WHAT YOUR PRODUCT IS. SO PLEASE DO NOT USE MY NAME OR EMAIL ADDRESS. YOU HAVE THE WRONG PERSON
09/03/2022
formosa p.
Verified Buyer
US
good stuff very strong
good stuff very strong give alot energy
01/23/2022
Ali M.
Verified Buyer
LT
Question :)
Hello. I live in Russia and am starting an Actovegin cycle after having gotten good results from Cortexin. Injecting once every other day would be the ideal scenario, from the instructions i read on your website. However, is it unsafe to inject 5ml everyday for 2 weeks? If you can elaborate, i'd appreciate it. Thank you.
11/23/2021
Gerrard H.
Verified Buyer
CA
Wow
It’s amazing it heals all my injuries 25 % faster
09/10/2021
Mieszko S.
Verified Buyer
PL
Perfect preparation
It works very well. Intravenous or muscle application works and works as it should. In my case, the inflammation of the shoulder tendons is relieved and healed after a month of treatment.
05/31/2020
Andrey P.
Verified Buyer
RU
nice
nice
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