ADAPTOL ® (Mebicar)


Buy more, get it as low as


Only original pharmaceutical products that passed 3 stages of clinical trials.


Our products are produced on GMP or state licensed factories.


10% discount for paying in BTC or other cryptocurrency.


Convenient Payment by Visa or MasterCard.


Guaranteed delivery times and clear Reshipment & Refund Rules.


Different shipping methods and same or next day shipping.

Adaptol ® (Mebicar) is an anxiolytic medication with a chemical structure similar to metabolites in the human body. It does not have a negative effect on mental or physical performance and can be used as a daytime tranquilizer. Adaptol can treat depression, reduce anxiety, improve sleep, enhance cognitive functions and assist in smoking cessation.

Buy Adaptol with fast US delivery 📦 Save with the volume discount 📦

Synonyms Mebicar / Temgicoluril / Tetramethylglycoluril / Mebicarum / Mebikar / 1,3,4,6-Tetramethylglycoluril
Form: 20 pills of 300mg /  20 pills of 500mg
Form description: Round, flat cylindrical tablets of white or almost white color with a facet and a break line.
Active ingredient: Tetramethyltetraazabicyclooctandionum
Excipients: Methylcellulose, calcium stearate.
СAS Number: 10095-06-4
ATC code: N06BX21
Pharmacological action: Anxiolytic
Shelf life: 4 years. Do not use it beyond the expiration date printed on the package.
Storage conditions: Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep out of reach of children.
Terms of release:  Requires prescription
Manufacturer: OlainFarm, Latvia / TatChemPharmPreparaty, Russia


What is Adaptol?

Adaptol (also known as Mebicar) is a daytime tranquilizer. Mebicar belongs to a group of non-benzodizepam tranquilizers. From the chemical perspective, it is a derivative of carbamide, an endogenous metabolite, which explains why the compound is 150 times less toxic than Diazepam.

What is the Mechanism of Action of Adaptol?

Adaptol affects the emotiogenic zones of the hypothalamus. It has an effect on 4 major neurotransmitter systems: GABAergic, cholinergic, serotonergic and adrenergic. It contributes to their balance and integration without a peripheral adrenoceptor blocking effect.

It decreases brain norepinephrine levels and increases brain serotonin levels without modulating dopaminergic systems or cholinergic systems.

Here you can find the script of the video.

What are the Benefits and Effects of Adaptol?

  • Adaptol can prevent and reduce anxiety, fear, tension, and irritability. Its anxiolytic effect is not accompanied by muscle relaxation, impaired coordination of movements, an elevated mood, a feeling of euphoria, or reduced mental or physical activity, so Adaptol can be used during the daytime.
  • Adaptol can enhance the effect of hypnotics and improve disturbed sleep.
  • Adaptol is said to relieve nicotine withdrawal.
  • Adaptol has a nootropic effect. It improves cognitive functions, attention, and mental performance without stimulating delirium or pathological emotional activity.

What is Adaptol Used For?

You can use Adaptol (Mebicar) to treat the following symptoms:

  • Asthenic disorders;
  • Depressions with anxiety;
  • Various conditions characterized by reduced mental productivity;
  • Extreme work conditions, e.g. excessive mental or physical exertion;
  • Nicotine withdrawal;
  • Impaired memory formation.

Where Can I Order Adaptol Online?

You can buy Adaptol (Mebicar) online at different vendors. CosmicNootropic offers Adaptol in packs of 20x300mg pills and 20x500mg pills. We offer fast US delivery and worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Adaptol and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.




Legal Disclaimer
This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

What is Adaptol Dosage?

The recommended dose is 900–1800 mg per day: 300–600 mg 3 times a day. The duration of treatment can vary from several days to 2 months.

If taken to relieve nicotine withdrawal symptoms, the recommended dose is 300–900 mg three times a day for 5-6 weeks.

What are the Side Effects of Adaptol?

Possible side effects include allergic reactions (itchy skin), headaches, hypotension (low blood pressure), and low body temperature.


An increase in potential side effects.


Anecdotal reports in Russia show that Mebicar provides a good rapid effect in the majority of cases without causing sleepiness and grogginess. However, in 8–12% of all cases, the drug appears either to be ineffective or to cause side effects.



  1. Zimakova et al (1980) Effect of mebikar on the state of animals under extreme conditions
  2. Valdman et al (1980) Characteristics of the psychotropic spectrum of action of mebicar
  3. S Kirshin, I Zimakova (1982) GABA-ergic component in the action of the tranquilizing agent mebikar
  4. Zimakova et al (1986) Evaluation of the nootropic effect of mebikar in clinical practice
  5. Zalesov et al (1988) Experimental and clinical study of the effectiveness of the combined use of anticonvulsants and tranquilizers in epilepsy
  6. Chutko et al (2009) Adaptol in the treatment of ADHD
  7. Mokina et al (2009) Experience of application of adaptol in treatment of chronic fatigue syndrome in patients with chronic cerebral ischemia
  8. Chutko et al (2009) The use of adaptol in the treatment of tick hyperkinesis is children
  9. Chutko et al (2010) Clinical and neurophysiological study of the efficacy of adaptol in the treatment of emotional burn-out
  10. K Tursunova, L Chutko (2011) Adaptol in the treatment of chronic cervicogenic headache
  11. E Barantsevich, O Posokhina (2011) Clinical-neurophysiological study of efficacy of adaptol in discirculatory encephalopathy
  12. V Mkrtchian, L Kozhokova (2012) Adaptol-verges of possible
  13. Shilina et al (2013) Efficacy of adaptol and the possibility of its differential use in patients with anxiety disorders after myocardial infarction
  14. S Duma et al (2013) Efficiency of using the anxiolytic adaptol in the combination therapy of arterial hypertension in women
  15. Orlov et al (2014) Clinical efficiency of combined therapy using adaptol for atopic dermatitis
  16. Chutko et al (2014) Asthenic disorders in children and their differentiated treatment
  17. Khaziakhmetova et al (2015) Experimental comparative study of the analgesic activity of the diurnal anxiolytic mebicar, amitriptyline, and diazepam
  18. V Vorob’eva, V Repina (2016) An open comparative observational study of the efficacy and safety of adaptol in anxiety-asthenic disorders in patients with chronic cerebral ischemia
  19. J Zhitkova, D Hasanova (2017) An experience of using mebicar in patients with autonomic dysfunction associated with anxiety disorder
  20. Kim et al (2018) Preventive Effect of Mebicar and Ginsenoside Rg1 on Neurobehavioral and Immunological Disruptions Caused by Intermittent Unpredictable Stress in Mice
  21. Kuzmenko et al (2020) [Current trends in the treatment of chronic recurrent bacterial cystitis]
  22. Kotova et al (2022) [Sleep disorders in post-COVID syndrome – a problem of psychiatry or neurology?]

Related products

Pantocalcin® is a nootropic drug that is used in the treatment of various neurotic disorders and psychoemotional stress. Its active ingredient Hopantenic acid has neuroprotective, neurometabolic and neurotrophic properties. Pantocalcin is often prescribed as a part of complex therapy for the normalization of the brain function.





Buy Adaptogens Bundle to find your perfect adaptogenic supplement or stack without spending lots of money. The Adaptogens Bundle contains 5 most popular products in the category. CosmicNootropic Bundles are perfect for finding supplements that work best for you. US fast delivery and international shipping available! 





Buy Anxiolytics Bundle to find your perfect anxiolytic supplement or stack without spending lots of money. The Anxiolytics Bundle contains 5 most popular products in the category. CosmicNootropic Bundles are perfect for finding supplements that work best for you. US fast delivery and international shipping available!