ADAPTOL ® (Mebicar)
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Adaptol ® (Mebicar) is an anxiolytic medication with a chemical structure similar to metabolites in the human body. It does not have a negative effect on mental or physical performance and can be used as a daytime tranquilizer. Adaptol can treat depression, reduce anxiety, improve sleep, enhance cognitive functions and assist in smoking cessation.
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|Synonyms||Mebicar / Temgicoluril / Tetramethylglycoluril / Mebicarum / Mebikar / 1,3,4,6-Tetramethylglycoluril|
|Form:||20 pills of 300mg / 20 pills of 500mg|
|Form description:||Round, flat cylindrical tablets of white or almost white color with a facet and a break line.|
|Excipients:||Methylcellulose, calcium stearate.|
|Shelf life:||4 years. Do not use it beyond the expiration date printed on the package.|
|Storage conditions:||Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep out of reach of children.|
|Terms of release:||Requires prescription|
|Manufacturer:||OlainFarm, Latvia / TatChemPharmPreparaty, Russia|
What is Adaptol?
Adaptol (also known as Mebicar) is a daytime tranquilizer. Mebicar belongs to a group of non-benzodizepam tranquilizers. From the chemical perspective, it is a derivative of carbamide, an endogenous metabolite, which explains why the compound is 150 times less toxic than Diazepam.
What is the Mechanism of Action of Adaptol?
Adaptol affects the emotiogenic zones of the hypothalamus. It has an effect on 4 major neurotransmitter systems: GABAergic, cholinergic, serotonergic and adrenergic. It contributes to their balance and integration without a peripheral adrenoceptor blocking effect.
It decreases brain norepinephrine levels and increases brain serotonin levels without modulating dopaminergic systems or cholinergic systems.
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What are the Benefits and Effects of Adaptol?
- Adaptol can prevent and reduce anxiety, fear, tension, and irritability. Its anxiolytic effect is not accompanied by muscle relaxation, impaired coordination of movements, an elevated mood, a feeling of euphoria, or reduced mental or physical activity, so Adaptol can be used during the daytime.
- Adaptol can enhance the effect of hypnotics and improve disturbed sleep.
- Adaptol is said to relieve nicotine withdrawal.
- Adaptol has a nootropic effect. It improves cognitive functions, attention, and mental performance without stimulating delirium or pathological emotional activity.
What is Adaptol Used For?
You can use Adaptol (Mebicar) to treat the following symptoms:
- Asthenic disorders;
- Depressions with anxiety;
- Various conditions characterized by reduced mental productivity;
- Extreme work conditions, e.g. excessive mental or physical exertion;
- Nicotine withdrawal;
- Impaired memory formation.
Where Can I Order Adaptol Online?
You can buy Adaptol (Mebicar) online at different vendors. CosmicNootropic offers Adaptol in packs of 20x300mg pills and 20x500mg pills. We offer fast US delivery and worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.
You can order Adaptol and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.
This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more
What is Adaptol Dosage?
The recommended dose is 900–1800 mg per day: 300–600 mg 3 times a day. The duration of treatment can vary from several days to 2 months.
If taken to relieve nicotine withdrawal symptoms, the recommended dose is 300–900 mg three times a day for 5-6 weeks.
What are the Side Effects of Adaptol?
Possible side effects include allergic reactions (itchy skin), headaches, hypotension (low blood pressure), and low body temperature.
An increase in potential side effects.
Anecdotal reports in Russia show that Mebicar provides a good rapid effect in the majority of cases without causing sleepiness and grogginess. However, in 8–12% of all cases, the drug appears either to be ineffective or to cause side effects.
- Zimakova et al (1980) Effect of mebikar on the state of animals under extreme conditions https://www.ncbi.nlm.nih.gov/pubmed/7439369
- Valdman et al (1980) Characteristics of the psychotropic spectrum of action of mebicar https://www.ncbi.nlm.nih.gov/pubmed/6104993
- S Kirshin, I Zimakova (1982) GABA-ergic component in the action of the tranquilizing agent mebikar https://www.ncbi.nlm.nih.gov/pubmed/7075749
- Zimakova et al (1986) Evaluation of the nootropic effect of mebikar in clinical practice https://www.ncbi.nlm.nih.gov/pubmed/3770177
- Zalesov et al (1988) Experimental and clinical study of the effectiveness of the combined use of anticonvulsants and tranquilizers in epilepsy https://www.ncbi.nlm.nih.gov/pubmed/3188750
- Chutko et al (2009) Adaptol in the treatment of ADHD https://www.ncbi.nlm.nih.gov/pubmed/19738569
- Mokina et al (2009) Experience of application of adaptol in treatment of chronic fatigue syndrome in patients with chronic cerebral ischemia https://www.ncbi.nlm.nih.gov/pubmed/19685596
- Chutko et al (2009) The use of adaptol in the treatment of tick hyperkinesis is children https://www.ncbi.nlm.nih.gov/pubmed/20209680
- Chutko et al (2010) Clinical and neurophysiological study of the efficacy of adaptol in the treatment of emotional burn-out https://www.ncbi.nlm.nih.gov/pubmed/21183911
- K Tursunova, L Chutko (2011) Adaptol in the treatment of chronic cervicogenic headache https://www.ncbi.nlm.nih.gov/pubmed/21905338
- E Barantsevich, O Posokhina (2011) Clinical-neurophysiological study of efficacy of adaptol in discirculatory encephalopathy https://www.ncbi.nlm.nih.gov/pubmed/22027612
- V Mkrtchian, L Kozhokova (2012) Adaptol-verges of possible https://www.ncbi.nlm.nih.gov/pubmed/23534281
- Shilina et al (2013) Efficacy of adaptol and the possibility of its differential use in patients with anxiety disorders after myocardial infarction https://www.ncbi.nlm.nih.gov/pubmed/24261227
- S Duma et al (2013) Efficiency of using the anxiolytic adaptol in the combination therapy of arterial hypertension in women https://www.ncbi.nlm.nih.gov/pubmed/23808300
- Orlov et al (2014) Clinical efficiency of combined therapy using adaptol for atopic dermatitis https://www.ncbi.nlm.nih.gov/pubmed/25026806
- Chutko et al (2014) Asthenic disorders in children and their differentiated treatment https://www.ncbi.nlm.nih.gov/pubmed/25726788
- Khaziakhmetova et al (2015) Experimental comparative study of the analgesic activity of the diurnal anxiolytic mebicar, amitriptyline, and diazepam https://www.ncbi.nlm.nih.gov/pubmed/26036004
- V Vorob’eva, V Repina (2016) An open comparative observational study of the efficacy and safety of adaptol in anxiety-asthenic disorders in patients with chronic cerebral ischemia https://www.ncbi.nlm.nih.gov/pubmed/27070467
- J Zhitkova, D Hasanova (2017) An experience of using mebicar in patients with autonomic dysfunction associated with anxiety disorder https://www.ncbi.nlm.nih.gov/pubmed/29265088
- Kim et al (2018) Preventive Effect of Mebicar and Ginsenoside Rg1 on Neurobehavioral and Immunological Disruptions Caused by Intermittent Unpredictable Stress in Mice https://www.ncbi.nlm.nih.gov/pubmed/29920498
- Kuzmenko et al (2020) [Current trends in the treatment of chronic recurrent bacterial cystitis] https://pubmed.ncbi.nlm.nih.gov/33377679/
- Kotova et al (2022) [Sleep disorders in post-COVID syndrome – a problem of psychiatry or neurology?] https://pubmed.ncbi.nlm.nih.gov/35759562/
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