Dosage and Administration
The drug is administered rectally, one suppository per day, preferably at the same time at night. The course is 1–3 months. The patient needs to lie on his side, bend the knees, then remove the package from a suppository and insert it deep into the rectum. For the next 30-40 minutes, the patient should not change his body position.
The use of the drug can provoke diarrhea. In most cases, the digestive system recovers on its own without any specific treatment.
The drug is not recommended for men with hypersensitivity to the substances included in the composition of the drug. If there is any doubt concerning the reaction of the body to the active substance, for the first time it is recommended to administer a suppository several hours before bedtime.
Prostate cancer is a strict contraindication against the prescription of the drug. It is also not recommended to use the drug in case of acute urinary retention.
Compatibility with alcohol: alcohol intake negatively affects the condition of the prostate gland, the circulatory system in the pelvic area and the functioning of the urinary system. The combination of the drug with alcohol reduces the effectiveness of the treatment, hence it is recommended to refrain from the alcohol consumption even in minimal quantities during the therapy.
Nowadays structural analogues of Adenoprosin® with the same active substance do not exist.
Nowadays, a very large number of patients suffer from chronic prostatitis and benign prostatic hyperplasia (BPH). In the daily practice of urologists, these diseases take up almost 95% of all the symptomatics. With such high incidence rates, various drugs can be used in clinical practice. In addition to chemical drugs, there are biological ones that are actively used in therapy. Moreover, today more and more patients prefer biological drugs, fearing certain adverse effects that sometimes occur in traditional chemical drugs.
One of such biological preparations is Adenoprosin®, an original European drug used for the treatment of BPH and chronic prostatitis. The active substance of the product contains lipoproteins, which are obtained from insect larvae of the Lymantria dispar species (the gypsy moth). The obtained biomass has antioxidant, vascular protective, anti-inflammatory and immunomodulation properties. The effectiveness of the drug is determined by the cumulative effect of the active components of the biological mass.
Under the action of Adenoprosin®, the size of the prostate gland decreases due to the induction of apoptosis; the growth of prostate gland cells is inhibited and the antioxidant effect is achieved due to the reduction of intracellular hydrogen peroxide; the anti-inflammatory effect is manifested due to the inhibition of extracellular pro-inflammatory cytokines and anti-angiogenic effect; apoptosis is inhibited when the cells are in inflammatory environment. In general, the drug demonstrates the following properties:
- Reduction of symptoms of BPH;
- Improvement of urodynamics;
- Reduction of the size of the hyperplastic prostate.
- Ghicavii, V et al (2011). New Direction in the Treatment of Benign Prostate Hyperplasia Using Adenoprosin: Biologically Active Entomological Medicine. https://www.goldjournal.net/article/S0090-4295(11)00914-9/fulltext
- Shalekenov BU et al (2012). The use of Adenoprosin 250 mg rectal suppositories in the complex treatment of chronic prostatitis and benign prostatic hyperplasia. https://cyberleninka.ru/article/n/primenenie-adenoprosina-250-mg-suppozitorii-v-kompleksnom-lechenii-hronicheskogo-prostatita-i-dobrokachestvennoy-giperplazii/viewer
- Dumbraveanu Ion et al (2017). Anti-inflammatory activity of Adenoprosin in nonbacterial prostatitis. https://journals.indexcopernicus.com/search/article?articleId=1980403