BEMITIL ® (Metaprot)
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Developed in the Soviet Union for the needs of the military, Bemitil (also known as Metaprot and AntiHot) has a long history of usage in clinical practice and in sport. It was developed in the 1970s and was successfully used during the Afghanistan war, the Chernobyl catastrophe, and the Olympic Games in Moscow.
The main purpose of Bemitil is to increase the physical and mental performance in people exposed to stressful conditions and accelerating the recovery process after physical exertion. That makes it useful for athletes, especially for bodybuilders and runners. What is important is that even healthy individuals can feel the benefits of the Bemitil.
But sport is not its only off-label usage. Bemitil works synergistically with other nootropics and can potentiate their effect, which makes this drug a possible part of a nootropic stack. According to clinical studies, the combination of Metaprot with the standard nootropic therapy is significantly more effective in the treatment of chronic fatigue, than standard therapy alone.
Bemitil has quite a wide field of application in clinical practice, too. In Russian medicine, this drug is used in the complex treatment of:
- Asthenic conditions (chronic fatigue);
- Traumatic brain injuries;
- Meningitis, encephalitis;
- Cerebrovascular and cognitive disorders.
Mechanism of action
The chemical structure of Bemitil is similar to that of nucleobases adenine and guanine, which can explain its pharmacological effects.
Bemitil increases the expression of RNA and proteins in the skeletal muscle, brain cells, liver, and kidneys. It also stimulates ATP formation and gluconeogenesis. Gluconeogenesis is the process of the formation of glucose from non-carbohydrate substrates, such as lactate, fats, and glucogenic amino acids, which plays an important role in the energy supply during exercise. Fasting, physical exercises, and a low-carb diet rich in proteins and fats have also been shown to stimulate gluconeogenesis.
Check out this viadeo about Bemitil:
Produced by Belmedpreparaty, Belarus.
This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more
Dosage and administration
Orally, after a meal.
For adults with body mass below 80 kg: two capsules in the morning, one capsule in the daytime (3 capsules a day).
For adults with body mass above 80 kg: two capsules in the morning, two capsules in the daytime (4 capsules a day).
The drug should be taken by a 5-days course. To avoid accumulation, another 5-day days course is suggested after a two days break.
To increase working performance in extreme conditions the drug should be taken 40–60 minutes prior to work at the 500–750 mg dosage. The maximum number of courses – two 5-day courses with two days break.
Hypersensitivity to any ingredients of the medication, hypoglycemia, pronounced liver dysfunctions, epilepsy, psychomotor agitation, arterial hypertension, glaucoma, ischemic heart disease, arrhythmia, lactase deficiency, lactose intolerance, glucose-galactose malabsorption, pregnancy, lactation, and age below 18 years.
The frequency of side effects: very often (above 10%), often (1–10%), infrequent (0.1–1%), rare (0.01–0.1%), very rare (<0.01%, including isolated cases with undefined frequency).
Central nervous system
Very often: headaches, facial hyperemia, sleep disturbances, anxiety;
Very rare: paresthesia, spasms.
Very rare: hypertension, tachycardia.
Rare: nausea, vomiting, liver and stomach discomfort.
Often: hives, allergic conjunctivitis, allergic rhinitis If the side effects occur, including those that were not listed in this instruction, you should cease using the drug and seek medical advice.
Symptoms: agitation and sleep disturbances.
If the signs of the overdose occur, the dosage should be reduced or the treatment ceased. Overdose treatment: gastric lavage, administration of activated charcoal, if necessary, symptomatic therapy.
Do not take in the evening time (may cause sleep disturbances). While taking this drug, constant monitoring of arterial pressure is necessary. The usage of the drug Bemitil is not recommended for people with suicidal behavior and for those who experienced suicidal thoughts before treatment. In case of behavior alteration or appearance of suicidal thoughts, patients should inform their doctor immediately.
RUE Belmedpreparaty, Belarus.
- Kibalchich et al (2011) Pharmacokinetics of domestic actoprotector drug Metaprot in healthy volunteers https://www.ncbi.nlm.nih.gov/pubmed/21870773
- Lucas et al (2012) Metaprotein expression modeling for label-free quantitative proteomics https://www.ncbi.nlm.nih.gov/pubmed/22559859
- Vorobeva et al (2012) Protective effects of metaprot and ethomerzol in carbophos intoxications https://wwww.unboundmedicine.com/medline/citation/23012992/[Protective_effects_of_metaprot_and_ethomerzol_in_carbophos_intoxications
- S Oliynyk, O Seikwan (2012) The Pharmacology of Actoprotectors: Practical Application for Improvement of Mental and Physical Performance https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762282/
- I Zarubina et al (2015) Antioxidant Effect of Polyoxidonium and Metaprot during Bronchopulmonary Inflammation in Rats https://www.ncbi.nlm.nih.gov/m/pubmed/26621277/
- V Yasnetsov et al (2016) Studying some pharmacological effects of new 3-hydroxypyridine derivative https://www.ncbi.nlm.nih.gov/m/pubmed/27416675/
- Kwiatkowska et al (2018) Detection of bemitil and its metabolite in urine by means of LC-MS/MS in view of doping control analysis https://www.ncbi.nlm.nih.gov/pubmed/30346653
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