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Recommended 2 Month Course is 3 packs x 10 ml vials Get it with the volume discount!

Cortexin is a mixture of neuropeptide fractions, amino acids, vitamins, and minerals, all of which have a mild positive effect on the brain. Similar to Cerebrolysin, Cortexin is based on neuropeptides and amino acids. However, there is a difference: Cortexin has a significantly larger amount of peptide fractions and fewer amino acids. While the former is produced from pig brains only, the latter is extracted mostly from young horned cattle cerebral cortex by acetic acid extraction. For more information on the comparison of the two compounds please read our blog post

Cortexin comes in injection form only: 10 mg – for adults, and 5 mg – for children. 

Cortexin has the following effects:

  • Nootropic effect: improves higher cerebral functions, processes of learning and memory, concentration, attention, and tolerance to mental and physical stress;
  • Neuroprotective effect: protects neurons against different endogenous neurotoxic factors (glutamate, calcium ions, and free radicals) and reduces the toxic impact of psychotropic agents;
  • Antioxidant effect: inhibits lipid peroxidation, increases survival of neurons under oxidative stress and hypoxia;
  • Tissue-specific effect: activates metabolism of neurons of the central and peripheral nervous system as well as reparative processes; also, promotes stimulation of cortical function and general improvement of the nervous system.


Cortexin composition

Amino acids: Aspartic acid 446 nmol/mg; Glycine 298 nmol/mg; Threonine 212 nmol/mg; Serine 268 nmol/mg; Glutamic acid 581 nmol/mg; Proline 187 nmol/mg; Alanine 246 nmol/mg; Isoleucine 356 nmol/mg; Tyrosine 109 nmol/mg; Phenylalanine 162 nmol/mg; Histidine 116 nmol/mg; Lysine 253 nmol/mg; Arginine and other amino acids 202 nmol/mg.

Vitamins: Lysine 253 nmol/mg; Thiamine (Vitamin B1) 0.08 mcg/10mg; Riboflavin (Vitamin B2) 0.03 mcg/10 mg; Niacin (Vitamin B3, Vitamin PP) 0.05 mcg/10 mg; Retinol (Vitamin A) 0.011 mcg/10mg; Alfa-tokoferol (vitamin E) 0.007 mcg/10mg.

Minerals: (Cu) 0.2129 mcg/10 mg; (Fe) 2.26 mcg/10 mg; (Ca) 22.93 mcg/10 mg; (Mg) 8.5 mcg/10 mg; (K) 19.83 mcg/10 mg; (Na) 643.2 mcg/10 mg; (S) 152.65 mcg/10 mg; (P) 91.95 mcg/10 mg; (Zn) 4.73 mcg/10 mg; (Mb) 0.0203 mcg/10 mg; (Co) 0.0044 mcg/10 mg; (Mn) 0.0061 mcg/10 mg; (Se) 0.0745 mcg/10 mg; (Al) 0.3104 mcg/10 mg; (Li) 0,0340 mcg/10 mg.

Produced by GEROPHARM, Russia. Read more about the producer in this blog post. Also, check the information about Cortexin from the manufacturer.

Legal Disclaimer
This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

Dosage and administration

Cortexin has indication-specific dosing, with the most common regime being intramuscular injections once daily: 10 mg per day for the period of 10 days for adults. For pediatric dosage please refer to the official instruction. If necessary, the course can be repeated after 3–6 months of discontinuation. 

Cortexin must be taken in the first part of the day, before 3 p.m.

Please use sterile needles, sterilize the administration site, wear sterile plastic gloves, and administer as soon as you open the vial. Before injection dissolve the content of the vial in 1-2 ml of 0.5% procaine (Novocain) solution, water for injection, or 0.9% sodium chloride solution. Relax your muscles and inject slowly.

Side effects

No adverse reactions were observed during administration when taken as indicated. Individual hypersensitivity to the product components is possible, please pay close attention to your body response when you administer the drug for the first time.


Geropharm, Russia.


  1.  Coulter et al (1993) Identification of cortexin: a novel, neuron-specific, 82-residue membrane protein enriched in rodent cerebral cortex
  2. Khavinson et al (1999) Cortexin effectiveness in circulatory encephalopathy
  3. Shabanov et al (2007) Comparison of behavioral effects of cortexin and cerebrolysin injected into brain ventricles
  4. Shabanov et al (2007) Comparative study of behavioral effects of cortexin and cerebrolysine upon intraventricular and intraperitoneal administration in rats
  5. Nurguzhaev et al (2009) Use of cortexin in the early rehabilitation period of ischemic stroke of moderate severity
  6. B Gafurov, Sh Gafurov (2010) Cortexin in the complex treatment of post stroke epilepsy
  7. A Solov’ev, T Elistratova (2010) Effectiveness of cortexin in the complex treatment of patients with chronic alcohol encephalopathy and polyneuropathy
  8. Mendzheritsky et al (2015) Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia
  9. Belova et al (2016) Efficacy of cortexin in acute and recovery periodes of hemispheric ischemic stroke
  10. Yakovlev et al (2017) Peptide drug cortexin inhibits brain caspase-8
  11. A Yakovlev, N. Gulyaeva (2017) Molecular partners of Cortexin in the brain
  12. Zukov et al (2018) Results of a multicenter study on the efficacy of cortexin in treatment of cognitive dysfunction in children ttps://
  13. N Gulyaeva (2018) Molecular mechanisms of brain peptide-containing drugs: cortexin
  14. A Fedin (2018) The efficacy of cortexin and memantinol (memantine) in the treatment of cognitive impairment in patients with chronic cerebral ischemia
  15. Belova et al (2018) Efficacy of Korteksin in acute period of hemispheric ischemic stroke
  16. Fedin et al (2018) Dose-dependent effects of cortexin in chronic cerebral ischemia (results of a multicenter randomized controlled study)

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