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CORTEXIN ®

37 Reviews

Legal disclaimer

Cortexin has not been approved by the US FDA to treat, cure, or prevent any disease. An effective therapy often includes different drugs and using Cortexin as a mono-therapy might be ineffective and even dangerous.

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Cortexin is a complex of low molecular weight neuropeptides, amino acids, and vitamins derived from the cerebral cortex of cattle. Cortexin is similar to Cerebrolysin, but it has a significantly larger amount of peptide fractions and fewer amino acids.

One Course is 1 pack x 10 ml vials for 10 days.  The course can be repeated in 3-6 months.

Chemical name Cortexin
Form: 10 vials of 5mg / 10 vials of 10mg
Form description: Lyophilized powder or porous mass of white or white-yellowish color
Active ingredient: Cortexin® (complex of water-soluble polypeptide fractions): 5 mg in a 3 ml vial, and 10 mg in a 5 ml vial
Excipients: Glycine (stabilizer) – 6 mg in a 3 ml vial and 12 mg in a 5 ml vial.
СAS Number: 83270-84-2
ATC code: N06BX
Pharmacological action: Neuroprotective, nootropic, antioxidant, tissue-specific
Shelf life: 3 years. Do not use it beyond the expiration date printed on the package.
Storage conditions: Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep in a safe place out of reach of children.
Terms of release: Over-the-counter
Manufacturer: Gerofarm, Russia https://geropharm.com/

What is Cortexin?

Cortexin is a mixture of neuropeptide fractions, amino acids, vitamins, and minerals, all of which have a mild positive effect on the brain. Similar to Cerebrolysin, Cortexin is based on neuropeptides and amino acids. While the former is produced from pig brains only, the latter is extracted mostly from young horned cattle cerebral cortex by acetic acid extraction. For more information on the comparison of the two compounds please read our blog post

Cortexin comes in injection form only: 10 mg – for adults, and 5 mg – for children. 

What are the Benefits and Effects of Cortexin?

Cortexin has the following effects:

  • Nootropic effect: it improves higher cerebral functions, processes of learning and memory, concentration, attention, and tolerance to mental and physical stress;
  • Neuroprotective effect: Cortexin protects neurons against different endogenous neurotoxic factors (glutamate, calcium ions, and free radicals) and reduces the toxic impact of psychotropic agents;
  • Antioxidant effect: Cortexin inhibits lipid peroxidation, and increases the survival of neurons under oxidative stress and hypoxia;
  • Tissue-specific effect: this drug activates the metabolism of neurons of the central and peripheral nervous system as well as reparative processes; also, it promotes stimulation of cortical function and general improvement of the nervous system.

Wonder what the difference is between Cortexin and Cerebrolysin?

The answer is in the Cortexin video review via the link below

What is Cortexin Used for?

Intended uses of Cortexin are defined by its correction of impaired molecular and cellular processes. Cortexin injections are prescribed in the following cases:

  • cerebral circulation disorders;
  • encephalopathy of various genesis;
  • acute and chronic encephalitis and encephalomyelitis;
  • epilepsy;
  • traumatic brain injury and its consequences;
  • asthenia;
  • infantile cerebral palsy;
  • psychomotor and speech retardation in children;
  • cognitive disorders (dysfunction of memory and ideation);
  • reduced learning ability.

There is evidence that Cortexin may relieve post-COVID syndrome. [19]

What is Cortexin Composition?

Amino acids: Aspartic acid 446 nmol/mg; Glycine 298 nmol/mg; Threonine 212 nmol/mg; Serine 268 nmol/mg; Glutamic acid 581 nmol/mg; Proline 187 nmol/mg; Alanine 246 nmol/mg; Isoleucine 356 nmol/mg; Tyrosine 109 nmol/mg; Phenylalanine 162 nmol/mg; Histidine 116 nmol/mg; Lysine 253 nmol/mg; Arginine and other amino acids 202 nmol/mg.

Vitamins: Lysine 253 nmol/mg; Thiamine (Vitamin B1) 0.08 mcg/10mg; Riboflavin (Vitamin B2) 0.03 mcg/10 mg; Niacin (Vitamin B3, Vitamin PP) 0.05 mcg/10 mg; Retinol (Vitamin A) 0.011 mcg/10mg; Alfa-tokoferol (vitamin E) 0.007 mcg/10mg.

Minerals: (Cu) 0.2129 mcg/10 mg; (Fe) 2.26 mcg/10 mg; (Ca) 22.93 mcg/10 mg; (Mg) 8.5 mcg/10 mg; (K) 19.83 mcg/10 mg; (Na) 643.2 mcg/10 mg; (S) 152.65 mcg/10 mg; (P) 91.95 mcg/10 mg; (Zn) 4.73 mcg/10 mg; (Mb) 0.0203 mcg/10 mg; (Co) 0.0044 mcg/10 mg; (Mn) 0.0061 mcg/10 mg; (Se) 0.0745 mcg/10 mg; (Al) 0.3104 mcg/10 mg; (Li) 0,0340 mcg/10 mg.

Where Can I Order Cortexin Online?

You can order Cortexin online from different vendors. CosmicNootropic offers Cortexin in packs of 10x5mg and 10x10mg vials with worldwide shipping! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Cortexin and get it delivered to the USA, Europe, the UK, Asia, and many other destinations via CosmicNootropic.

What is Cortexin Dosage, How To Use?

Cortexin has indication-specific dosing. The most common regime is intramuscular injections once daily: 10 mg per day for a period of 10 days for adults. For pediatric dosage please refer to the official instruction. If necessary, the course can be repeated after 3–6 months of discontinuation. 

Cortexin shall be taken in the first part of the day, before 3 p.m.

Please use sterile needles, sterilize the administration site, wear sterile plastic gloves, and administer as soon as you open the vial. Before injection dissolve the content of the vial in 1-2 ml of 0.5% procaine (Novocain) solution, water for injection, or 0.9% sodium chloride solution. Relax your muscles and inject slowly.

What are the Side Effects of Cortexin?

No adverse reactions were observed during administration when taken as indicated. Individual hypersensitivity to the product components is possible. Please pay close attention to your body response when you administer the drug for the first time.

 

OFFICIAL INSTRUCTION

  1. Coulter et al (1993) Identification of cortexin: a novel, neuron-specific, 82-residue membrane protein enriched in rodent cerebral cortex https://www.ncbi.nlm.nih.gov/pubmed/8336151
  2. Khavinson et al (1999) Cortexin effectiveness in circulatory encephalopathy https://www.ncbi.nlm.nih.gov/pubmed/10356917
  3. Shabanov et al (2007) Comparison of behavioral effects of cortexin and cerebrolysin injected into brain ventricles https://www.ncbi.nlm.nih.gov/pubmed/18214294
  4. Shabanov et al (2007) Comparative study of behavioral effects of cortexin and cerebrolysine upon intraventricular and intraperitoneal administration in rats https://www.ncbi.nlm.nih.gov/pubmed/17650626
  5. Nurguzhaev et al (2009) Use of cortexin in the early rehabilitation period of ischemic stroke of moderate severity https://www.ncbi.nlm.nih.gov/pubmed/19672239
  6. B Gafurov, Sh Gafurov (2010) Cortexin in the complex treatment of post stroke epilepsy https://www.ncbi.nlm.nih.gov/pubmed/20873481
  7. A Solov’ev, T Elistratova (2010) Effectiveness of cortexin in the complex treatment of patients with chronic alcohol encephalopathy and polyneuropathy https://www.ncbi.nlm.nih.gov/pubmed/20517210
  8. Mendzheritsky et al (2015) Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia https://www.ncbi.nlm.nih.gov/pubmed/28509493
  9. Belova et al (2016) Efficacy of cortexin in acute and recovery periodes of hemispheric ischemic stroke https://www.ncbi.nlm.nih.gov/pubmed/27845314
  10. Yakovlev et al (2017) Peptide drug cortexin inhibits brain caspase-8 https://www.ncbi.nlm.nih.gov/pubmed/28251948
  11. A Yakovlev, N. Gulyaeva (2017) Molecular partners of Cortexin in the brain https://link.springer.com/article/10.1134/S1819712416040164
  12. Zukov et al (2018) Results of a multicenter study on the efficacy of cortexin in treatment of cognitive dysfunction in children ttps://www.ncbi.nlm.nih.gov/pubmed/29652302h
  13. N Gulyaeva (2018) Molecular mechanisms of brain peptide-containing drugs: cortexin https://www.ncbi.nlm.nih.gov/pubmed/30499504
  14. A Fedin (2018) The efficacy of cortexin and memantinol (memantine) in the treatment of cognitive impairment in patients with chronic cerebral ischemia https://www.ncbi.nlm.nih.gov/pubmed/29460902
  15. Belova et al (2018) Efficacy of Korteksin in acute period of hemispheric ischemic stroke https://www.ncbi.nlm.nih.gov/pubmed/30132453
  16. Fedin et al (2018) Dose-dependent effects of cortexin in chronic cerebral ischemia (results of a multicenter randomized controlled study) https://www.ncbi.nlm.nih.gov/pubmed/30335070
  17. Gulyaeva (2019) Molecular Mechanisms of the Actions of Brain Peptide-Containing Drugs: Cortexin https://link.springer.com/article/10.1007/s11055-019-00839-4
  18. Mashin et al (2019) [Evaluation of the efficacy and safety of application of the drug cortexin in the complex rehabilitation of verticalization in patients with ischemic stroke in the acute period] https://pubmed.ncbi.nlm.nih.gov/31626220/
  19. Putilina et al (2022) [Determination of the prevalence of postcovid syndrome and assessment of the effectiveness of the drug Cortexin in the treatment of neurological disorders in patients with postcovid syndrome. Results of the multicenter clinical and epidemiological observational program CORTEX] https://pubmed.ncbi.nlm.nih.gov/35175707/

4.4

Based on 37 Reviews

(30)

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(5)

 

05/23/2024

Sanije B.

Sanije B.

 Verified Buyer
DK

DK

terrible

It was terrible. I have not recieved my shipment and not refund! The policies of refundment are just terrible.

05/23/2024

Hi Sanije! We are so sorry to hear this, thank you for reaching out. We have emailed you to see what can be done in this situation.

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01/04/2024

Kevin

Kevin

PK

PK

Appreciable and lasting benefit

This is one of my top 3 nootropics. This stuff makes a noticeable difference in my focus and memory. And one 10-day course leaves a benefit that lasts a few weeks. After the first time I tried it, I never forgot where I parked for like 2 months. Normally that\'s always a problem for me. Of course it helps in other ways too besides parking.

01/04/2024

Dear Kevin, we are happy to hear that you are satisfied with this product :) Thank you for leaving the review!

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12/22/2023

Joshua

Joshua

Great Product

After 10 years of brain fog from Lyme disease I\'m finally seeing light at the end of the tunnel. I find that cortexin gives me more mental energy and clarity. I\'m suddenly remembering the words to songs I didn\'t know I knew lol. It is also helping with my anxiety. It seems to make my brain sharper than cerebrolisyn. In 6 months I would like to do another course of cortexin with cerebrolisyn.

12/22/2023

Hi Joshua! Thank you for finding a moment to leave a review. We're beyond happy to know that this product helped you with such a serious issue.

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12/05/2023

Jeff D.

Jeff D.

US

US

Bait and switched me

It boggles my mind that I paid for 10 vials, and they gave me a tracking # that had no cortexin in it at all. It\'s super infuriating. Only now, 11 days after paying for it, am I seeing the banner running saying you\'re out of stock. This is beyond unacceptable! People count on these meds and your company, with our lives and health depending on it, and this is what you let happen? Forcing me to source it elsewhere.

12/06/2023

Dear Jeff, We understand your frustration with the temporary delays in our warehouse and we deeply apologize. Now your order is on its way and will be delivered shortly. Please check your email.

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12/05/2023

Jeff D.

Jeff D.

US

US

Never got what I paid for!!!

Paid for 10 vials of cortexin and never got them!!

12/06/2023

Dear Jeff, your order is on its way and will be delivered shortly. Please check your email.

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0

12/03/2023

Kyle B.

Kyle B.

 Verified Buyer
US

US

Never received

I would have like the product if I ever receive it.

12/15/2023

Dear Kyle, we apologize for the recent delays at our US warehouse. We see now that you received your order on the Dec 11th and hope you're satisfied with the product.

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11/17/2023

Joseph L.

Joseph L.

 Verified Buyer
US

US

The best Noot out there

Saw immediate effects and cerebral enhancements. Loved it. Reordering every 3-4 months

12/14/2023

Dear Joseph, we're thrilled to know Cortexin is working for you. Thanks for being our loyal customer!

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11/02/2023

Kai N.

Kai N.

 Verified Buyer
GB

GB

It’s very good product. I feel clearly mind and have more concentration.

11/03/2023

Hi Kai! We are glad that the product worked for you!

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0

10/02/2023

henry b.

henry b.

 Verified Buyer
CA

CA

cortexin

cortexin really did help with my thinking.i will start another course in Nov.loved it

10/03/2023

Dear Henry, thank you for sharing your experience with our product. We are glad that it helps you!

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0

08/02/2023

Kandace M.

Kandace M.

 Verified Buyer
US

US

Amazing product

I love using Cortexin. It relieves my stress and anxiety almost immediately and it helps with concentration and focus. I keep this in my arsenal of peptides and bioregulators.

08/02/2023

Hi Kandace, thank you for the review! We're glad that you're satisfied with the product. :)

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06/05/2023

Dmitri S.

Dmitri S.

 Verified Buyer
US

US

Great service

All expectations satisfied!

06/07/2023

Hi Dmitri, thank you for your feedback! We're happy to hear that we met your expectations! :)

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0

05/16/2023

Jennifer M.

Jennifer M.

 Verified Buyer
US

US

Great Product Like Always

I really liked cortexin. Definitely something I will be alternating with Cerebro from here on.

05/19/2023

Hi Jennifer, thank you for your feedback! We're thrilled to hear that you had a great experience with Cortexin.

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04/30/2023

Tyler W.

Tyler W.

 Verified Buyer
US

US

Underrated Nootropic

I have no idea why cortexin and cerebrolysin aren't more widely used, they are both phenomenal for mental health and performance.

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0

04/04/2023

Justin A.

Justin A.

 Verified Buyer
US

US

Love this company

This company is legit!!! I love all of the products that I have purchased from them.

04/07/2023

Dear Justin, thank you so much for your review! We are happy to have you as our loyal customer :)

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03/28/2023

Jonathan L.

Jonathan L.

 Verified Buyer
GB

GB

Good products

I ordered cortexin - really helped with my concussion & cognition over all. Highly recommend

03/29/2023

Hi Jonathan, thank you for your feedback! We're happy that you're satisfied with the product! :)

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0

02/22/2023

Mikias A.

Mikias A.

 Verified Buyer
US

US

Long lasting cognitive increase

It feels like it resets my brain every time I cycle it.

02/24/2023

Thank you for your feedback!💛

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0

02/04/2023

Ivan

Ivan

 Verified Buyer
CA

CA

good experience

I had a good experience with cosmic so far, great service and shipping to Canada without issues.

02/05/2023

Thank you Ivan for your feedback, we really appreciate that!

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01/23/2023

Tamara F.

Tamara F.

 Verified Buyer
US

US

With Ease

Still waiting to try Cortexin, but wanted to say that working with Cosmic is stress free and a breeze! Thank you for all your help!

01/25/2023

Hi Tamara! Thank you very much for sharing your experience! 💙 Please let us know if you have any questions or need any help!

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11/13/2022

Lazarus L.

Lazarus L.

 Verified Buyer
US

US

Improved my life more than I ever hoped for

I bought this to try and help me with some memory issues I have been experiencing. It definitely helped with that but not to a huge extent. However, I also have some sensory nerve issues that I have not had diagnosed yet but were annoying. I have random parts of my body that are more sensitive than others and not like ordinary sensitive arm pits or soft tissue more like just random sensitive to touch areas. After taking one cycle of this stuff the sensitivity is a third of what it was! I did not expect this outcome and it never crossed my mind that Cortexin could help with sensory nerve issues. This has lead me to purchase 2 more cycles that I will use in the coming months. I can't describe how much this stuff has improved my life! I never felt normal like this and it's an amazing experience. Remember if you decide to purchase Cortexin to talk to your doctor first and do an hour or two a day of research for at least a week to be certain of its safety and whether the benefits are worth it to you. Thank you Cosmic Nootropics for giving me and others the ability to access these life improving medicines. I can't give your team enough thanks.

11/16/2022

Hi Lazarus, we're really happy that Cortexin helped you, and you feel much better now! Thank you for sharing your experience, it is really important. 💙

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06/19/2022

Jared L.

Jared L.

 Verified Buyer
CA

CA

With out a doubt works, and works fast

I injected one vial a day for 10 days straight… within 2-3 days, there was an obvious improvement in cognition and overall well-being. After a few days my long standing brain fog started to fade, my chronic fatigue improved to the point where I actually went a few days without napping (something I haven’t done in years), and my mood / overall sense of well-being showed a night and day difference. I was happier and more social - I know that wasn’t placebo since I met up with friends almost everyday (ever since covid, I’ve been much more isolated and somewhat of a “lone Wolfe”… I can’t set enough positive things about Cortexin, and will be doing another cycle in the next 4-6 months or so.

08/01/2022

Hi Jared, Thanks so much for sharing your experience with us! We're very glad that Cortexin helped you improve your condition. :)

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