buy Sulbutiamine


7 Reviews

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All statements on this page are for informational purposes only and have not been evaluated by the US FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Before using this product, consulting a qualified MD is mandatory. See more

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Buy Sulbutiamine (Enerion ®) Online!

Sulbutiamine (Enerion ®) is a synthetic substance similar to vitamin B1, though with better bioavailability. Sulbutiamine can have anti-fatigue, nootropic, anxiolytic, and antioxidant effects. It is used to treat symptoms of weakness or fatigue.

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Synonyms Arcalion / Enerion
Form: 20 pills of 200mg / 100 pills of 200mg
Form description: Double-radius, round tablets with an orange shell; a slight surface (the level of glossiness) or color inhomogeneity is permitted, insignificant impregnations are allowed.
Active ingredient: Sulbutiamine – 200 mg
Excipients: Corn starch, dried starch paste, anhydrous glucose (dextrose), lactose monohydrate, magnesium stearate, talc.
Capsule shell composition: sodium hydrocarbonate, sodium carboxymethylcellulose, white beeswax, titanium dioxide (E171), ethylcellulose, “Sunset” yellow FCF, E110, glycerol monooleate, polysorbate 80, povidone, sucrose, colloidal anhydrous silicon dioxide (Aerosil 130), talc.
СAS Number: 3286-46-2
ATC code: A11DA02
Pharmacological action: Regulation of metabolic processes in the central nervous system
Shelf life: 3 years. Do not use it beyond the expiration date printed on the package.
Storage conditions: Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep out of reach of children.
Terms of release: Over-the-counter
Manufacturer: Servier, France


What is Sulbitiamine?

Sulbutiamine (Enerion) is modified thiamine (vitamin B1), first synthesized by Japanese researchers in the mid-60s. It can easily cross the blood-brain barrier. In the brain it eventually produces both GABA and acetylcholine, thus affecting adaptability, mood, and focus.

What are the Benefits and Effects of Sulbitiamine?

Due to its structural difference from thiamine, Sulbutiamine is well soluble in fat. It is quickly absorbed from the digestive tract and easily penetrates into the blood-brain barrier (BBB). In contrast to thiamine, it can accumulate in the cells of the reticular formation, in the hippocampus and the dentate gyrus, as well as in the Purkinje cells and in the glomeruli of the granular layer of the cerebellar cortex. Sulbitiamine is said to improve physical endurance and coordination of movement, and the stability of the cerebral cortex structures becomes more resistant to repeated anoxia. The medicine is effective for the symptomatic treatment of functional asthenia.

Sulbutiamine is reported to have anti-fatigue, nootropic, anxiolytic, and antioxidant effects.

What is Sulbutiamine Used For?

Sulbutiamine is used to treat asthenia (symptoms of fatigue or weakness). It is also used to treat thiamine deficiency and poor concentration. Being a potent cholinergic anxiolytic, Sulbutiamine is a popular nootropic, with users reporting enhanced memory, focus, and improved mood and motivation. Endurance athletes may use it to try to enhance their performance.


Official indications for Sulbutiamine use include:

  • Symptomatic treatment of asthenic disorders;
  • Hypovitaminosis and avitaminosis;
  • Lingering illnesses;
  • After surgical interventions.

Where Can I Order Sulbutiamine Online?

You can buy Sulbutiamine (Enerion) online at different vendors. CosmicNootropic offers Sulbutiamine in packs of 20x200mg pills and 100x200mg pills. We offer worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Sulbutiamine and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.

Legal Disclaimer
This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

What is Sulbutiamine Dosage?

The daily dose is 2-3 tablets (400–600 mg) divided into 2 intakes (during breakfast and lunch). The duration of treatment should not exceed 4 weeks. Enerion is recommended for adult patients only.

What are the Side Effects of Sulbutiamine?

Side effects occur very rarely, with the most common being increased irritability and hyperkinesia (excessive abnormal movements). Possible side effects may include allergic reactions (presence of “Sunset” yellow in the composition of the medication), digestive disorders, psychoneurological reactions (tremor, headache, agitation, general malaise).


Transient agitation and tremors. These symptoms do not require special treatment.



  1. Micheau et al (1985) Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation
  2. Tiev et al (1999) Treatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine (400-600 mg/day) versus placebo
  3. O Van Reeth (1999) Pharmacologic and therapeutic features of sulbutiamine
  4. Trovero et al (2000) Evidence for a modulatory effect of sulbutiamine on glutamatergic and dopaminergic cortical transmissions in the rat brain
  5. Loo et al (2000) Effects of sulbutiamine (Arcalion 200) on psycho-behavioral inhibition in major depressive episodes
  6. Kiew et al (2002) Effects of Sulbutiamine on Diabetic Polyneuropathy: An Open Randomised Controlled Study in Type 2 Diabetics
  7. Vein et al (2003) Use of enerion in psychovegetative syndrome with pronounced asthenia
  8. S Shah (2003) Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia
  9. Bizot et al (2005) Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task
  10. Dmitriev et al (2005) Clinical efficacy of the drug enerion in the treatment of patients with psychogenic (functional) erectile dysfunction
  11. Litvinovich et al (2006) The use of sulbuthiamine (enerion) in the combined therapy of patients with symptomatic focal epilepsy
  12. Ollat et al (2007) Effects of the association of sulbutiamine with an acetylcholinesterase inhibitor in early stage and moderate Alzheimer disease
  13. O Levin, L Slizakova (2007) The use of enerion in the treatment of asthenic disorders in patients after mild cranio-cerebral trauma
  14. T Sobolevsky, G Rodchenkov (2010) Sulbutiamine in sports
  15. Kang et al (2010) Sulbutiamine counteracts trophic factor deprivation induced apoptotic cell death in transformed retinal ganglion cells
  16. Kwag et al (2011) Evidence for neuroprotective effect of sulbutiamine against oxygen-glucose deprivation in rat hippocampal CA1 pyramidal neurons
  17. Farid et al (2016) Stability-Indicating HPTLC Method for Studying Stress Degradation Behavior of Sulbutiamine HCl
  18. Sevim et al (2017) Sulbutiamine shows promising results in reducing fatigue in patients with multiple sclerosis
  19. Starling-Soares et al (2020) Role of the Synthetic B1 Vitamin Sulbutiamine on Health
  20. Y Bykov, R Bekker (2022) [On the specific treatment of asthenic states: focus on sulbutiamine]


Based on 7 Reviews








Marianni R.

Marianni R.

 Verified Buyer


No use no results

Saw no results.


Hi Marianni! We are sorry that the product did not work for you. For most nootropics, the effect can be varied for different people. It strongly depends on the personal conditions, so we always recommend consulting a specialist before taking any medication.

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 Verified Buyer


Enerion back on my shelf

Gives me splitting headaches.


Dear Eric, we are sorry to hear that you did not like the product. For most nootropics, the effect can be varied for different people. It strongly depends on the personal conditions, so we always recommend consulting a specialist before taking any medication.

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Sean K.

Sean K.

 Verified Buyer


Puts me to sleep.

Bought it for the anti-fatigue aspect which is an issue I have naturally and exacerbated by stopping Adderall. But, this drug puts me to sleep. Does help me sleep a bit better but I was really hoping it would reduce fatigue and help keep me awake. Seems to decrease effect quickly, don\'t seem to sleep as well for as long when started it. Does mention a GABA effect which may be what makes me sleepy. Also mentions a boost to Acetylcholine. Perhaps I end up with too much Acetylcholine since I take supplements like Alpha GPC and Huperzine A and some others that have an effect on Acetylcholine. But, can\'t really tell for sure if that is the reason or something else. I am naturally very sensitive to anything that makes you drowsy.


Dear Sean, Thank you for sharing your experience of taking our product. We are sorry that the product was not suitable for you. For most nootropics, the effect can be varied for different people. It strongly depends on the personal conditions, so we always recommend consulting a specialist before taking any medication.

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John C.

John C.

 Verified Buyer


Everything about the product was great

The product was of high quality both in packaging and formulation. It also arrived in a timely fashion. This did seem to assist maintaining a proper energy level throughout the day.


Hi John, Thanks for sharing your experience!

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Øystein S.

 Verified Buyer

quick delivery and good prices

although payment method is a bit different from other shops, CN staff was very helpful every step of the way, extraordinarily quick in their response to emails. Will definitely purchase from CN again.

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Michelle A.

 Verified Buyer

Enerion sulbutiamine

I did not feel much of an effect, not enough to buy again.


Hi Michelle, Thank you for sharing your experience. The effects of the Eneriaon are rather subtle and their intensity depends on the patient. We do not recommend to exceed the official dosage as it may lead to unpleasant side effects. Best regards, Andrey

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 Verified Buyer


Great products, great quality, and great service. Cosmic Nootropic is my go to for quality and authentic products. Thanks you Cosmic Nootropic and the team.

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