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EPITALON ® (Epithalon)

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All statements on this page are for informational purposes only and have not been evaluated by the US FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Before using this product, consulting a qualified MD is mandatory. See more

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Buy Epitalon spray. Bioregulator supplement for the pineal gland to reverse the aging process. 

Other names: Epitalon, Epithalon, Ala-Glu-Asp-Gly, L-Alanyl-L-glutamyl-L-aspartyl-glycine, Khavinson peptide
Form: Oral spray (20ml)
Active ingredients:  Per daily dosage (1ml) of the peptide complex: Alanine – 0.125mg, Glutamic acid – 0.125mg, Aspartic acid – 0.125mg, Glycine – 0.125mg.
Excipients:  Water, sodium benzoate, potassium sorbate
Molecular formula: C14H22N4O9
СAS Number: 307297-39-8
Type: Dietary supplement
Shelf life: 5 years. Do not use it beyond the expiration date printed on the package.
Storage: Store at temperatures not exceeding 25°C (77°F). Do not freeze. Protect from light.
Manufacturer: NANOPEP, Portugal



Epitalon (Epithalon, AGAG, AEDG) is a synthetic short peptide made of four amino acids: alanine, glutamic acid, aspartic acid, and glycine (Ala–Glu–Asp–Gly). It was developed at the St. Petersburg Institute of Bioregulation and Gerontology by Prof. Vladimir Khavinson using a patented technology. 

Epitalon helps to restore the proper functioning of the pineal gland and launch the production of the necessary amount of melatonin. This can reverse the aging process. Epitalon spray health benefits are backed by years of scientific research. Check out the Research tab to learn more.


Epitalon has gained recognition for its special properties to regulate melatonin an important hormone in the human body that is secreted by the epiphysis (pineal gland). Epitalon helps the body to normalize the production of its own endogenous melatonin. The result of using Epitalon is a general well-being, restoration of sleep, and normalization of metabolism. Epitalon accelerates falling asleep, improves sleep quality and reduces the number of night awakenings.

Epitalon ultra-short peptide activates telomerase enzyme that fights cancerous tumors and suppresses the cancer gene. Epitalon polypeptide alters telomerase activity and adds nucleotides – telomeres to the DNA chain, which helps to stabilize telomeres. [9]

Due to the fact that epiphysis peptides in Epitalon have a short nano-formula, they act quickly and come into effect almost instantly. The biotechnological feature of the action of short peptides classifies them as cell-penetrating peptides (CPPs). Epitalon comes in the form of an oral spray, with which the peptide is directly delivered into the bloodstream without passing through the digestive system. This ensures faster and better absorption of the active component in comparison to tablets. 


  • Age-related disorders;
  • Sleep disorders;
  • Fatigue, stress;
  • Weakened immunity;
  • Disturbed biorhythms;
  • Jet lag (sleep disturbance after long flights);
  • Hormonal disorders.


You can purchase peptide Epitalon at CosmicNootropic. We offer top-notch customer service and worldwide delivery.

Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.



Epitalon spray is applied sublingually. Spray 3 times under the tongue twice per day before the meal in the morning and in the afternoon. The course duration is 20 days. It is advised to repeat the course every 4–6 months.


Short peptides in Epitalon have an organ-specific effect and are natural in origin, which makes Epitalon safe to use with it being part of the natural metabolism of the body. Epitalon is not a hormonal drug. It does not have a toxic effect on the body. It has no side effects and does not cause complications and drug dependence. 


Epitalon is not recommended for children and adolescents. It is not recommended to exceed the dose without a doctor’s prescription.

  1. Dilman VM et al (1979). Increase in lifespan of rats following polypeptide pineal extract treatment.
  2. Pisarev OA, Khavinson VKh et al (1982). Isolation, physico-chemical and biological properties of the immunity polypeptide bioregulator from thymus.
  3. Alexandrov VA, et al (1996). Study of the post-natal effects of chemopreventive agents on ethylnitrosourea-induced transplacental carcinogenesis in rats. II. Influence of low-molecular-weight polypeptide factors from the thymus, pineal gland, bone marrow, anterior hypothalamus, brain cortex and brain white substance.
  4. Lapin B et al (2001). Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys.
  5. Khavinson VKh (2002). Peptides and Ageing.
  6. Franceschi C et al (2002). Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/NEU transgenic mice.
  7. Khavinson VKh, Razumovsky M et al (2002). Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa.
  8. Zandbank J, et al (2003). Epitalon and colon carcinogenesis in rats: Proliferative activity and apoptosis in colon tumors and mucosa.
  9. Khavinson, VK, et al (2003). Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells.
  10. Vinogradova IA et al (2007). Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes.
  11. Lin’kova NS, Kuznik BI, Khavinson VKh (2012). Peptide Ala-Glu-Asp-Gly and interferon gamma: their role in immune response during aging.
  12. Vanyushin BF, Khavinson VKh (2016). Short Biologically Active Peptides as Epigenetic Modulators of Gene Activity.
  13. Khavinson VKh, Diomede F et al (2020). AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism.
  14. Official website of the manufacturer. Available at: (in English)


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