buy S-Adenosyl methionine


Only original pharmaceutical products that passed 3 stages of clinical trials.


Our products are produced on GMP or state licensed factories.


15% discount for paying in BTC or other cryptocurrency.


Convenient Payment by Visa or MasterCard.


Guaranteed delivery times and clear Reshipment & Refund Rules.


Different shipping methods and same or next day shipping.

S-Adenosyl Methionine (HEPTOR ®)

0 Reviews

Legal Disclaimer

All statements on this page are for informational purposes only and have not been evaluated by the US FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Before using this product, consulting a qualified MD is mandatory. See more

Buy more, get it as low as

Save 5%
Save 7%
Save 9%
Save 11%
Save 12%
Save 13%
Save 14%
9 +
Save 15%
Show More

Buy S-Adenosyl Methionine (Heptor®) Online!

S-Adenosyl Methionine (Heptor ®) is a hepatoprotector with anti-inflammatory, painkiller and antidepressant effects. Heptor can relieve pain and stimulate tissue regeneration in patients with osteoarthritis. Also, it can be used to reduce withdrawal symptoms in patients with opioid addiction.

Save with the volume discount!

Synonyms Ademetionine / S-Adenosyl-L-methionine / SAM / SAM-e / SAMe / AdoMet / Heparab / Ademethionine
Form: 20 pills of 400mg
Form description: Enteric-coated yellow oblong biconvex tablets
Active ingredient: Ademetionine – 400 mg
Excipients: Crospovidone 19 mg, microcrystalline cellulose 53 mg, mannitol 53 mg, magnesium stearate 15 mg.
СAS Number: 29908-03-0
ATC code: A16AA02
Pharmacological action: Drugs used in addictive disorders, drugs used in nicotine addiction
Shelf life: 3 years. Do not use it beyond the expiration date printed on the package.
Storage conditions: Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep out of reach of children.
Terms of release: Over-the-counter
Manufacturer: Veropharm, Russia


What is Ademetionine (S-Adenosyl Methionine)?

S-Adenosyl Methionine (Heptor ®) or Ademetionine is a drug currently considered one of the most powerful hepatoprotectors. Ademetionine takes part in transmethylation and is a biosynthetic precursor of cysteine, taurine, and glutathione. Apart from its hepatoprotective properties, ademetionine also has anti-inflammatory, painkiller, and antidepressant effects. Heptor is a choleretic and cholekinetic drug.

What is the Mechanism of Action of Heptor (S-Adenosyl Methionine)?

As a hepatoprotector, Heptor replenishes ademetionine deficiency and stimulates its production in the brain and liver. As a part of transmethylation, it elevates glutamine levels in the liver and increases plasma cysteine and taurine concentration. It also lowers the concentration of methionine in serum which helps stabilize the metabolic functions of the liver. Heptor acts as a precursor of polyamines: putrescine which stimulates cell regeneration, spermidine, and spermine, which are compounds of ribosomes and living tissues.

The choleretic effect of the drug is driven by the synthesis of phosphatidylcholine in hepatocyte membranes which increases their mobility. This enhances the function of the biliary system. The drug is effective in the case of bile secretion disorders, including cholestasis.

What are the Benefits and Effects of Heptor (S-Adenosyl Methionine)?

  • The use of the drug in patients with osteoarthritis helps relieve pain and stimulates proteoglycan synthesis and cartilage tissue regeneration.
  • Heptor also has detoxifying, regenerating, antioxidant, antifibrotic, and neuroprotective properties.
  • The drug was shown to be effective in patients with hepatopathy caused by hepatotoxic drugs.
  • You can buy S-Adenosyl methionine for use in patients with opioid addiction accompanied by liver damage as it helps reduce manifestations of withdrawal symptoms and improves the functional state of the liver.
  • Antidepressant effects of the drug increase gradually starting from the 2nd week of treatment. Heptor treatment is recommended in case of recurrent endogenous and neurotic depressions. Research demonstrated that the drug is effective in treating depression relapse.

What is Heptor (S-Adenosyl Methionine) Used For?

On-label use of Ademetionine (S-Adenosyl Methionine) includes treatment of the following conditions:

  • Hepatitis of various origins: toxic, viral, drug-induced (caused by antibiotics, anticancer drugs, anti-tuberculosis and antiviral drugs, tricyclic antidepressants, and oral contraceptives);
  • Intrahepatic cholestasis;
  • Cirrhosis;
  • Secondary metabolic encephalopathy;
  • Depressive disorder;
  • Alcohol withdrawal syndrome.

Where Can I Order Heptor Online?

You can buy Ademetionine (S-Adenosyl Methionine) online at different vendors. CosmicNootropic offers Heptor (S-Adenosyl Methionine) in packs of 20x400mg pills. We offer worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Ademetionine and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.

What is Ademetionine Dosage?

The average daily dose is 800–1,600 mg (2–4 pills). The recommended duration of treatment is 2–4 weeks.

What are the Side Effects of Ademetionine (S-Adenosyl Methionine)?

Possible side effects include nausea, abdominal pain, diarrhea, insomnia, headache, and allergic response.


  • Genetic disorders affecting the methionine cycle and/or causing homocystinuria/hyperhomocysteinemia;
  • Children under 18 years of age;
  • Hypersensitivity to the components of the drug.

Drug interaction

To be used with caution when co-administered with selective serotonin reuptake inhibitors, tricyclic antidepressants, or drugs containing tryptophan.

  1. Cozens et al (1988) Reproductive toxicity studies of ademetionine
  2. Domljan et al (1989) A double-blind trial of ademetionine vs naproxen in activated gonarthrosis
  3. P Almasio, L Pagliaro (1993) Ademetionine: the state of the art and future prospects
  4. M Frezza (1993) A meta-analysis of therapeutic trials with ademetionine in the treatment of intrahepatic cholestasis
  5. Bottiglieri et al (1994) The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders
  6. T Bottiglieri (1997) Ademetionine (S-adenosylmethionine) neuropharmacology: implications for drug therapies in psychiatric and neurological disorders
  7. Qin et al (2000) A trial of ademetionine in the treatment of intrahepatic biliary stasis viral hepatitis
  8. L Il’chenko, E Vinnitskaia (2002) Metabolism pathways and use of heptral in chronic liver diseases
  9. G Vostrikov, A Toporkov (2002) Use of heptral in chronic liver diseases
  10. Arnold et al (2005) Double-blind, placebo-controlled pharmacodynamic studies with a nutraceutical and a pharmaceutical dose of ademetionine(SAMe) in elderly subjects, utilizing EEG mapping and psychometry
  11. Tkachenko et al (2008) Clinical efficacy of ademetionine “Heptor” in the therapy of alcohol-dependent liver disease
  12. Zhu et al (2010) Efficacy and safety of ademetionine for treatment of drug-induced liver disease in children
  13. Shilov et al (2012) Comparative evaluation of clinical efficacy of drugs remaxol and ademetionine in patients with acute ethanol poisoning complicated by the toxic damage of the liver
  14. Sukhanov et al (2013) Hepato- and endothelioprotective action of runihol and ademetionine in experimental liver injury induced by TB drugs in combination with alcohol
  15. Tian et al (2013) Protective effect of ademetionine 1, 4-butanedisulfonate on liver injury caused by chemotherapeutic agents
  16. D Sukhanov (2013) Antioxidant properties of remaxol, reamberin, and ademetioninein patients with drug-induced liver injury on the background of antituberculous therapy
  17. Virukalpattigopalratnam et al (2013) Heptral (ademetionine) in patients with intrahepatic cholestasis in chronic liver disease due to non-alcoholic liver disease: results of a multicentre observational study in India
  18. Guo et al (2015) S-Adenosyl-L-Methionine for the Treatment of Chronic Liver Disease: A Systematic Review and Meta-Analysis
  19. Tong et al (2015) Effect of ademetionine on cytochrome P450 isoforms activity in rats
  20. Stelmakh et al (2015) Efficacy of the infusion hepatotropic drug remaxol in the pathogenetic therapy for cirrhotic stage chronic viral hepatitides
  21. Sharma et al (2017) S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research
  22. Ivashkin et al (2018) Open-label study of ademetionine for the treatment of intrahepatic cholestasis associated with alcoholic liver disease
  24. Borzacchiello et al (2022) S-Adenosylmethionine Inhibits Colorectal Cancer Cell Migration through Mirna-Mediated Targeting of Notch Signaling Pathway
  25. Ullah et al (2022) Efficacy of a food supplement based on S-adenosyl methionine and probiotic strains in subjects with subthreshold depression and mild-to-moderate depression: A monocentric, randomized, cross-over, double-blind, placebo-controlled clinical trial


Based on 0 Reviews







Thank you!

You will now receive regular updates from us!