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Hypoxenum is an adaptogen developed in 1976 by a group of scientists in the Institute of Macromolecular Compounds of the Academy of Sciences of the USSR, Leningrad. The active compound of Hypoxen is Sodium salt of (poly-(2,5-dihydroxy-phenylene))-4-thiosulfonic acid. Hypoxenum and coenzyme Q10 have a similar structure.

Hypoxen was shown to have antihypoxic and antioxidant effects and can be used by healthy people with reduced performance in extreme situations and adverse weather conditions, e.g. Far North, highlands, etc. Hypoxenum is used by athletes to improve physical performance, yet it is not on the WADA Prohibited List: during Olympics 2022, Kamila Valieva, a figure skater of the Russian Olympic Committee, reportedly took Hypoxen.

Apart from that, the drug was also shown to be effective in patients suffering from alcohol abuse problems as it can decrease cravings, improve mood, lower anxiety, and asthenia.

Hypoxen can be used in the combination therapy of conditions associated with hypoxia: severe injuries, burns, major surgery, blood loss, as well as asthma and obstructive bronchitis, pneumonia, and insufficient oxygen supply to the issues. Moreover, Hypoxenum reduces the amount of damage caused to the heart by myocardial infarction; the drug also activates the functional activity of monocytes in patients with viral hepatitis, recurrent herpes, influenza, and acute respiratory viral infections (ARVI).

In 1996, the drug was approved for medical use and has been sold without prescription in Russia since then.

Off-label use of Hypoxenum includes treatment of patients with addictive disorders such as the relief of alcohol withdrawal. As was shown in this study, Hypoxenum possesses high efficacy as a drug used to relieve withdrawal symptoms in the period of post abstinence.

The active compound of the drug is also patented in the USA.

Produced by Valenta Pharm / Olifen Pharmaceutical Factory, Russia.

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Pharmacodynamic properties

Hypoxenum prevents lipid peroxidation and stimulates the destruction of its products. It stimulates the oxidation of accumulated reduced equivalents during the post-hypoxic period due to Nicotinamide adenine dinucleotide phosphate or NADP⁺. It optimizes mitochondrial function, enhances tissue respiration and mitochondria aerobic respiration, reduces the hypoxia negative effects, as a result increasing endurance and mental performance.

Pharmacological effect

Antihypoxic and antioxidant effects. Hypoxenum has electron acceptor properties due to its polyphenolic structure, shunts the electron transport chain of mitochondria and enhances tissue respiration. The thiosulfate group gives Hypoxenum a pronounced antiradical and antioxidant effect.

Dosage and administration

Hypoxenum dosage is calculated individually based on the patient’s needs, body weight, and indications.

Body weight, kg Daily dose, capsules
60–70 3–4
70–80 4–6
80–90 6–8
90–100 8–10
100–120 10–12

One daily dose 30–60 minutes before exercise should be taken to treat hypoxia in the following situations:

  • Alveolar hypoventilation;
  • Highlands;
  • Underwater work;
  • Working in high temperatures;
  • Endurance training.


One-half daily dose 2 times a day for 2-3 weeks should be taken in the following situations:

  • Long-term intense mental activity;
  • Chronic fatigue;
  • Reducing the recovery period after excessive physical exertion;
  • Injuries and surgery.


*** Administration of two pills per day for 14 days was shown to be effective for the alleviation of alcohol withdrawal symptoms.

Treatment courses can be repeated with intervals of 1-2 weeks in-between.

Side effects

Allergic response.


Main symptoms: abdominal pain, nausea, dry mouth, and respiratory depression in rare cases.

Treatment: gastric lavage, activated carbon administration, and symptomatic treatment.


Valenta Pharm / Olifen Pharmaceutical Factory, Russia.


  1. Karpova et al (2002) Antimutagenic hypoxen activity in vivo https://www.ncbi.nlm.nih.gov/pubmed/12227099
  2. Kosenko et al (2010) The drug hypoxen: A new inhibitor of mitochondrial respiration and dehydrogenases https://link.springer.com/article/10.1134/S1062359010040035
  3. Murzaeva et al (2010) Effect of hypoxenum on bioenergetic processes in mitochondria and the activity of ATP-sensitive potassium channel https://www.ncbi.nlm.nih.gov/pubmed/21033347
  4. Novikov et al (2010) Gastroprotective properties of mexidol and hypoxen https://wwww.unboundmedicine.com/medline/citation/20597364/[Gastroprotective_properties_of_mexidol_and_hypoxen]
  5. Dugieva et al (2012) Impact of hypoxen therapy on postoperative course in gynecologic patients https://www.ncbi.nlm.nih.gov/pubmed/23156041
  6. Novikov et al (2012) Changes in chemiluminescence of whole blood of COPD patients treated with Hypoxen® and effects of C60 fullerenes on blood chemiluminescence https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560587/

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