Limontar [Citric and Succinic Acids]

Formulation and Packaging

Soluble tablets 50 mg + 200 mg.

Active ingredients include succinic acid 200 mg and citric acid monohydrate 50 mg.

Active ingredient: magnesium stearate 3 mg.

Application and dosage

To be administered orally before meal. Crush and dilute a tablet in water with a pinch of baking soda or mineral water.

Dosage for pregnant women is 250 mg a day. It is recommended to take several 10-14 day treatment courses during pregnancy. 

Dosage for preventing alcohol intoxication is 250 mg 20-60 minutes before intake of ethanol. In case of alcohol intoxication it is recommended to take 250 mg 3-4 times a day for 4-10 days independently or in combination with other medicines.

Dosage for improving appetite is 250 mg 1-3 times a day before meal for 3-5 days. In case of a feeling of tightness or abdominal pains it is recommended to take the drug after meal.

Counterindcations

  • hypersensitivity;
  • arterial hypertension;
  • ischemic heart disease (including angina pectoris);
  • glaucoma;
  • acute peptic ulcer;
  • late gestosis.

Side Effects

Gastralgia, hypersecretion of gastric juice and increase in blood pressure in patients prone to hypertension.

Drug Interaction

The drug lowers the effect of sleeping pills and tranquilizers. 

Storage Conditions

Store at dark place at a temperature of 25 °C (77 °F).

Keep out of the reach of children.

Manufacturer

Medical Research and Production Complex BIOTIKI, Russia

Limontar is a combination drug which stabilizes tissue metabolism. It has antihypoxic and antioxidant properties, improves appetite and reduces the toxic effect of ethanol.

It enhances the oxidation-reduction processes and the production of adenosine triphosphate (ATP), and thus it: 

  • activates functions of organs and tissues, 
  • improves mental and physical performance, 
  • enhances pregnancy outcome, fetal growth and development, and 
  • stabilizes secretion of the gastric acid, production of hydrochloric acid. 

Its main ingredients are citric and succinic acid. Succinic acid is a dicarboxylic acid which has been shown to stimulate neural system recovery and bolster the immune system. Succinate supplements help reduce the effects of hangovers by activating the degradation of acetaldehyde - a toxic byproduct of alcohol metabolism - into CO2 and H2O through aerobic metabolism. 

Citric acid is involved in energy metabolism and Krebs cycle. It facilitates minerals absorption, prevents kidney stone formation and has many other uses in healthcare, food and chemical industries.

The effect of Limontar is manifests within 10-20 min after the intake.

Citric and succinic acid are completely metabolized into water and carbon dioxide and do not accumulate in the body.

Indications

  • enhancement of body reactivity during pregnancy; 
  • prevention of hypoxia complications during pregnancy; 
  • prevention of alcohol intoxication;
  • treatment of acute alcohol intoxication;
  • treatment of astheno-vegetative syndrome followed by asthenia, lowered performance and poor appetite;
  • as part of test of gastric acid secretion.

  1. Kodama et al (1982) Organic acid metabolism in a patient with ornithine transcarbamylase deficiency https://www.ncbi.nlm.nih.gov/pubmed/7116641
  2. Kaneuchi et al (1988) Production of Succinic Acid from Citric Acid and Related Acids by Lactobacillus Strains https://www.ncbi.nlm.nih.gov/pmc/articles/PMC204426/
  3. MacDonald et al (1989) Effect of esters of succinic acid and other citric acid cycle intermediates on insulin release and inositol phosphate formation by pancreatic islets https://www.ncbi.nlm.nih.gov/pubmed/2645827
  4. Korneev et al (1995) The protective action of limontar in pregnant animals with acute hypoxic hypoxia https://www.ncbi.nlm.nih.gov/pubmed/8704587
  5. Volchegorskii et al (2015) Antidepressant effect of 3-oxypyridine and succinic acid derivatives (experimental study)  https://www.ncbi.nlm.nih.gov/pubmed/26081324


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