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Mebicar®
20 Reviews
Description
Dosage
Research
Reviews
Pharmacological Profile
| Synonyms | Mebicar / Temgicoluril / Tetramethylglycoluril / Mebicarum / Mebikar / 1,3,4,6-Tetramethylglycoluril |
| Form: | 20 pills of 300mg / 20 pills of 500mg |
| Form description: | Round, flat cylindrical tablets of white or almost white color with a facet and a break line. |
| Active ingredient: | Tetramethyltetraazabicyclooctandionum |
| Excipients: | Methylcellulose, calcium stearate. |
| СAS Number: | 10095-06-4 |
| ATC code: | N06BX21 |
| Pharmacological action: | Anxiolytic |
| Shelf life: | 4 years. Do not use it beyond the expiration date printed on the package. |
| Storage conditions: | Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep out of reach of children. |
| Terms of release: | Requires prescription |
| Manufacturer: | TatChemPharmPreparaty, Russia / Latvia |
What is Mebicar?
Mebicar is a daytime tranquilizer. Mebicar belongs to a group of non-benzodizepam tranquilizers. From the chemical perspective, it is a derivative of carbamide, an endogenous metabolite, which explains why the compound is 150 times less toxic than Diazepam.
What is Mebicar Used For?
You can use Mebicar to treat the following symptoms:
- Asthenic disorders;
- Depressions with anxiety;
- Various conditions characterized by reduced mental productivity;
- Extreme work conditions, e.g. excessive mental or physical exertion;
- Nicotine withdrawal;
- Impaired memory formation.
More detailed information about the studies on the application can be found in the Dosage tab.
What are the Benefits and Effects of Mebicar?
- Mebicar can prevent and reduce anxiety, fear, tension, and irritability. Its anxiolytic effect is not accompanied by muscle relaxation, impaired coordination of movements, an elevated mood, a feeling of euphoria, or reduced mental or physical activity, so Mebicar can be used during the daytime.
- Mebicar can enhance the effect of hypnotics and improve disturbed sleep.
- Mebicar is said to relieve nicotine withdrawal.
- Mebicar has a nootropic effect. It improves cognitive functions, attention, and mental performance without stimulating delirium or pathological emotional activity.
Is Mebicar Safe to Take?
The toxicity of Mebicar is very low. It does not create high spirits and a sense of euphoria. It does not have the drowsiness effect. Though be sure to consult with a healthcare professional if you have any questions or health concerns. Contraindications include hypersensitivity to the components of the drug, age below 18 years, pregnancy and lactation.
FAQ
What is Mebicar’s Mechanism of Action?
Mebicar affects the emotiogenic zones of the hypothalamus. It has an effect on 4 major neurotransmitter systems: GABAergic, cholinergic, serotonergic, and adrenergic. It contributes to their balance and integration without a peripheral adrenoceptor-blocking effect.
It decreases brain norepinephrine levels and increases brain serotonin levels without modulating dopaminergic systems or cholinergic systems.
What is Adaptol?
Adaptol (also known as Mebicar or Temgicoluril) is a mild anxiolytic – a medication designed to reduce anxiety, stress, and emotional tension without causing sedation or dependency. It helps calm the nervous system while maintaining mental clarity, focus, and productivity.
What is Mebicar Dosage?
The recommended dose is 900–1800 mg per day: 300–600 mg 3 times a day. The duration of treatment can vary from several days to 2 months.
If taken to relieve nicotine withdrawal symptoms, the recommended dose is 300–900 mg three times a day for 5-6 weeks.
What are Mebicar Side Effects?
Possible side effects include allergic reactions (itchy skin), headaches, hypotension (low blood pressure), and low body temperature.
Instructions
- Zimakova et al (1980) Effect of mebikar on the state of animals under extreme conditions, PubMed
- Valdman et al (1980) Characteristics of the psychotropic spectrum of action of mebicar, PubMed
- S Kirshin, I Zimakova (1982) GABA-ergic component in the action of the tranquilizing agent mebikar, PubMed
- Zimakova et al (1986) Evaluation of the nootropic effect of mebikar in clinical practice ,PubMed
- Zalesov et al (1988) Experimental and clinical study of the effectiveness of the combined use of anticonvulsants and tranquilizers in epilepsy , PubMed
- Chutko et al (2009) Adaptol in the treatment of ADHD , PubMed
- Mokina et al (2009) Experience of application of adaptol in treatment of chronic fatigue syndrome in patients with chronic cerebral ischemia , PubMed
- Chutko et al (2009) The use of adaptol in the treatment of tick hyperkinesis is children , PubMed
- Chutko et al (2010) Clinical and neurophysiological study of the efficacy of adaptol in the treatment of emotional burn-out , PubMed
- K Tursunova, L Chutko (2011) Adaptol in the treatment of chronic cervicogenic headache , PubMed
- E Barantsevich, O Posokhina (2011) Clinical-neurophysiological study of efficacy of adaptol in discirculatory encephalopathy , PubMed
- V Mkrtchian, L Kozhokova (2012) Adaptol-verges of possible , PubMed
- Shilina et al (2013) Efficacy of adaptol and the possibility of its differential use in patients with anxiety disorders after myocardial infarction
- S Duma et al (2013) Efficiency of using the anxiolytic adaptol in the combination therapy of arterial hypertension in women , PubMed
- Orlov et al (2014) Clinical efficiency of combined therapy using adaptol for atopic dermatitis , PubMed
- Chutko et al (2014) Asthenic disorders in children and their differentiated treatment , PubMed
- Khaziakhmetova et al (2015) Experimental comparative study of the analgesic activity of the diurnal anxiolytic mebicar, amitriptyline, and diazepam , PubMed
- V Vorob’eva, V Repina (2016) An open comparative observational study of the efficacy and safety of adaptol in anxiety-asthenic disorders in patients with chronic cerebral ischemia, PubMed
- J Zhitkova, D Hasanova (2017) An experience of using mebicar in patients with autonomic dysfunction associated with anxiety disorder , PubMed
- Kim et al (2018) Preventive Effect of Mebicar and Ginsenoside Rg1 on Neurobehavioral and Immunological Disruptions Caused by Intermittent Unpredictable Stress in Mice , PubMed
- Kuzmenko et al (2020) [Current trends in the treatment of chronic recurrent bacterial cystitis] , PubMed
- Kotova et al (2022) [Sleep disorders in post-COVID syndrome – a problem of psychiatry or neurology?], PubMed
4.2
Based on 20 Reviews
(14)
(1)
(1)
(2)
(2)
10/05/2025
Trevor B.
Verified Buyer
US
Just didn’t help me with my anxiety.
This company seems to be great…. Fast shipping all that it’s not that their fault just for me personally the medicines don’t work for me.
12/09/2024
Eddy..
Verified Buyer
US
For a purpose.
Trying to quit smoking, I have faith in placebos. Does it help, I\'m making the effort so it helps. Day Two: Took Phenibut, Mebicar and one other yesterday in half doses. Did not smoke, tripped. Thankfully my boss is an ex addict who understands mistakes. Go easy. I have addiction, ADHD issuesthis absolutely helps. I\'ve taken antidepressants with mixed results. the mood influencers are real.
12/10/2024
CosmicNootropic
Hi Eddy! Thank you for sharing your experience! It’s great to hear that Mebicar, along with your thoughtful efforts, is playing a role in your journey. Quitting smoking and managing ADHD or addiction can be challenging, and it’s inspiring to see you taking positive steps. We’re here to support you on your path, and we wish you continued success! �
08/25/2024
alex k.
Verified Buyer
US
not recommended
it's a really strange feeling
08/29/2024
CosmicNootropic
Hi Alex! Thank you for sharing your experience with us. We’re sorry to hear that the product didn’t meet your expectations. We’ve sent you an email to get more details about what you’re experiencing, so we can better assist you. Please check your inbox and provide us with additional information.
12/29/2023
Drew Y.
Verified Buyer
US
Not much of an effect
Gave this a try and it had no perceptible effect. I'd try it on days where I was in a sort of 'wire but tired' state which I figured this would be well-suited to help with, but even with experimenting up to 4 pills I got nothing from it. Maybe it would have worked under different circumstances but it was a no-go for me. I won't say I'm never going to try it again, but given how few pills you get in relation to its price the odds are low.
01/10/2024
CosmicNootropic
Hi Drew, we're sorry to hear that the product didn't work for you. 😔 For most nootropics, the effect can be varied for different people. It strongly depends on personal conditions, so we always recommend consulting a specialist before taking any medication.
06/06/2023
Lauren B.
Verified Buyer
US
Legit
The product was legit and as expected:)
06/07/2023
CosmicNootropic
Hi Lauren, thank you for your feedback.! :)
05/08/2023
William M.
Verified Buyer
US
Adaptol
Best product I know of to calm the nerves. Non addictive and safe. No side effects. Thank you CosmicNootropic.
05/11/2023
CosmicNootropic
Hi William, thank you for your feedback! We are happy to hear that you are satisfied with the product. :)
02/19/2023
Inna S.
Verified Buyer
US
Very happy with variety of choices and costumer service!
Great variety of choices, fast delivery. Overall, very happy
02/19/2023
CosmicNootropic
Dear Inna, thank you very much for your kind feedback!
01/18/2023
Inna S.
Verified Buyer
US
Very happy with variety of choices and costumer service!
Excellent costumer service, on-time delivery, great variety of supplements, reasonable prices.
01/22/2023
CosmicNootropic
Thank you Inna, we really appreciate your feedback!
10/24/2022
David N.
Verified Buyer
FR
I never received this item
I'n not giving a bad review, i imagine it's not easy witg all the delivery process but i want to let yoyu know that I never received it
10/26/2022
CosmicNootropic
Hi David, I'm sorry that your item did not arrive. We have contacted you via email to solve this problem. Please check your inbox!
01/25/2022
Jeffrey D.
Verified Buyer
US
Arrived on time and all, but I'm not sure if the pills did much.
I bought these to help with anxiety and sleep as I quit tobacco. It's kinda hard to subjectively say, but I didn't notice much of an effect. I tried taking 500mg and 1,000mg doses and didn't notice anything. I didn't experience anything negative or positive.
03/09/2022
CosmicNootropic
Dear Jeffrey, Sorry for the unpleasant experience. The thing is that the effect varies from person to person depending on the personal conditions. That's why we always recommend to consult a specialist before taking any meds. If needed, please reach out to support@cosmicnootropic.com and we can answer your questions in more detail.
02/13/2021
Anthony M.
Verified Buyer
US
Exactly as advertised!
Exactly as advertised! Very effective (2 tabs) to maintain focus and stay calm and in control in stressful situations! Which may be M-F at your job? This is great help!!
01/24/2021
Samuel L.
Verified Buyer
US
Effective product
Since I've started taking this product, its effects haven't suppressed the better side of my personality. It's still early in the treatment process, but my sense of this product is positive as it looks to be reflecting the effects indicated by trial research.
12/25/2019
Felipe S.
Verified BuyerGreat for rebalance
Great product. I used it to recover from an intensive practicum period. Sleep well and mood increased positively in about a week. However, it is a little on the strong side. We all react differently to chemistry changes in our neurons. I would buy this again.
10/19/2018
Michelle A.
Verified BuyerSide effects with Mebicar
Horrible side effects, allergic rhinitis burning on tongue, throat and mouth. Severe Headache. Would recommend nobody buy this product
11/30/-0001
CosmicNootropic
Hello Michelle, Without knowing your specific case we cannot recommend anything in this situation. There has been reports of such side effects previously, but they are rear and manifest themselves only if the patient is sensitive to the Mebicar. We strongly recommend to stop using Adaptol if you feel any worrying side effects. They should disappear as soon as you stop taking the supplement. Best regards, Andrey
10/16/2018
Nadezhda M.
Verified BuyerGreat service and product
I was very satisfied with the product and plan to do business again with them in the future.
10/16/2018
Nadezhda M.
Verified BuyerGreat service and product
I was very satisfied with the product and plan to do business again with them in the future.
02/21/2018
Ola A.
Verified BuyerSo many side effects
This product isn’t good at all, the side effects aren’t listed because not enough/ no clinical trail was conducted. After I took it, it make me feel drowsy I would sleep for 12hrs or longer. I started having different emotional feelings(very bad emotions and thought(s)), I felt like crying but couldn’t cry (this almost drove me crazy). I didn’t menstruate (this is on of the side effect when taking drugs that effects the NS),immediately I stopped taking it after two days my menstruation came. If all these side effects came and the medication made my anxiety good it would have been great and worth it, but didn’t do shit for my anxiety just gave me negative effects( my anxiety isn’t extreme it’s just occurs occasionally when I have presentations and something important coming up). I won’t ever buy these sh** every again, I got four packs and I had to throw them out, beware of self medication like these,( it even states it might not work, and it didn’t). Don’t waste your money, time and health on something you aren’t sure would work or help u, don’t take chances on your health.
11/30/-0001
CosmicNootropic
Hi Ola, We are sorry for your negative experience with Adaptol. As all the other medications it has negative side effects that may be severe, if the drug is taken excessively or patient has hypersensitivity to the ingredients of the drug. Such medication usually have cumulative effect, so positive perks don't come instantly. But, in any case, it was a wise decision to stop the treatment, since the side effects were so severe for you. All side effects should fade after you stop taking the drug, so there are no additional steps to be taken in that direction. If you need any other information or help don't hesitate to contact us any time via our e-mail. Regards, Andrey
01/13/2018
John C.
Verified BuyerDelivery to Malta
Excellent customer service and products
02/05/2017
Krys
Verified BuyerWORKS!
Quick delivery. Customer service excellent. Product itself as advertised and works. Product delivers subtle calmness and HD vision. Dosing is a bit inconvenient as you need more than one pack for it to last a month.
02/05/2017
Martin R
Verified BuyerALL GOOD SO FAR.
Ordered 3 boxes of Adaptol. I felt I took a risk here as from previous experience I know there are plenty of scammers on the scene. I was delighted to receive my order precisely one week from day of order. The tracking was a reassurance too and also fit for purpose (a rarity now sadly). Package arrived undamaged and not tampered with by customs (maybe I was lucky). The product looks legit but yet to test. Anyway, I'm pleasantly surprised and will without doubt use this vendor again soon. Thanks Ololoman.
