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IDEBENONE (Noben ®)
2 Reviews
Description
Dosage
Research
Reviews
Buy Idebenone capsules online!
Idebenone is a synthetic analog of coenzyme Q10 (CoQ10), an endogenous compound involved in mitochondrial energy production. Idebenone is a nootropic researched for the treatment of various neurological disorders. Idebenone was shown to improve cerebral blood flow, oxygen delivery to the brain, and metabolic processes.
| Synonyms | Catena / Raxone / Sovrima |
| Form: | 30 pills of 30mg |
| Form description: | Yellow capsules with granules and powder of yellow or yellow-orange color inside, orange and white patches are possible. |
| Active ingredient: | Idebenone – 30 mg |
| Excipients: | Lactose, microcrystalline cellulose, potato starch, low molecular weight povidone, magnesium stearate. |
| СAS Number: | 58186-27-9 |
| ATC code: | N06BX13 |
| Pharmacological action: | Nootropic |
| Shelf life: | 2 years. Do not use it beyond the expiration date printed on the package. |
| Storage conditions: | Store in a dry dark place at temperatures no higher than 30°C (86°F). Keep out of reach of children. |
| Terms of release: | Over-the-counter |
| Manufacturer: | Binnopharm / Abbott Laboratories |
What is Idebenone?
Idebenone is a modern neuroprotector with a universal mechanism of action. Idebenone is a synthesized coenzyme responsible for the generation of energy in nerve cells. It was first synthesized in Japan, at Takeda Pharmaceutical, to treat Alzheimer’s disease [1] and other memory loss disorders. Then the research was continued by European pharmacists.
A number of researchers recommend Idebenone for the treatment of various neurological disorders due to its nootropic pharmacology. Indeed, as a structural analog of CoQ10, it was shown to improve cerebral blood flow and oxygen delivery to the brain.[2] It can also improve metabolic processes, in particular, the synthesis of glucose and adenosine triphosphate (ATP) and lactate elimination. Also, idebenone can slow down the process of lipid peroxidation and protect membranes of neurons and mitochondria from damage.
What is Idebenone Used For?
The official manufacturer lists the following conditions:
- Multi-infarct dementia;
- Complex therapy after stroke or TBI;
- Symptoms of cerebrovascular diseases;
- Comprehensive treatment of migraine.
In 2007, idebenone was described as an orphan drug for the treatment of Leber’s hereditary optic neuropathy (LHON) by the European Medicines Agency (EMA).
What are the Benefits and Effects of Idebenone?
The research compound can be of help during intense intellectual and mental stress. It contributes to an improvement in the emotional state, removing the feeling of chronic fatigue, and reducing the severity and frequency of headaches. Noben is used in slowing down the aging process, and improving memory, attention, and well-being.
The active component of Noben restores the energy level in the brain cells during high physical tension, which in theory makes it possible to train longer and recover faster.
Is Idebenone Safe To Take?
Even though Noben (Idepenone) is considered quite safe and non-addictive, it still has contraindications (renal failure) and possible side effects which can aggravate in case of overdose. The main side effects include allergic reactions, headaches, insomnia, and dyspepsia.
What is Idepenone Dosage?
As per official instructions, the normal dose is 1 capsule (30 mg) 2-3 times per day. The duration of treatment may vary from 1 to 2 months. The course can be repeated after a 2-month break.
The product is not used for cure, mitigation, treatment, or prevention of any disease. Always consult a healthcare professional before using this product to determine if it is appropriate for you. For informational purposes, you may also refer to the official instructions provided by the manufacturer.
- Gillis et al (1994) Idebenone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in age-related cognitive disorders https://www.ncbi.nlm.nih.gov/pubmed/7981485
- H Gutzmann, D Hadler (1998) Sustained efficacy and safety of idebenone in the treatment of Alzheimer’s disease: update on a 2-year double-blind multicentre study https://www.ncbi.nlm.nih.gov/pubmed/9850939
- Gutzmann et al (2002) Safety and efficacy of idebenone versus tacrine in patients with Alzheimer’s disease: results of a randomized, double-blind, parallel-group multicenter study https://www.ncbi.nlm.nih.gov/pubmed/11819153
- Hausse et al (2002) Idebenone and reduced cardiac hypertrophy in Friedreich’s ataxia https://www.ncbi.nlm.nih.gov/pubmed/11907009
- Thai et al (2003) Idebenone treatment fails to slow cognitive decline in Alzheimer’s disease https://www.ncbi.nlm.nih.gov/pubmed/14663031
- McDaniel et al (2005) Clinical efficacy assessment in photodamaged skin of 0.5% and 1.0% idebenone https://www.ncbi.nlm.nih.gov/pubmed/17129261
- Di Prospero et al (2007) Neurological effects of high-dose idebenone in patients with Friedreich’s ataxia: a randomised, placebo-controlled trial https://www.ncbi.nlm.nih.gov/pubmed/17826341
- Schulz et al (2009) Clinical experience with high-dose idebenone in Friedreich ataxia https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277883/
- K Voronkova, M Meleshkov (2009) Use of Noben (idebenone) in the treatment of dementia and memory impairments without dementia https://www.ncbi.nlm.nih.gov/pubmed/19430983
- Klopstock et al (2011) A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170530/
- Gerhardt et al (2011) Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242749/
- Klopstock et al (2013) Persistence of the treatment effect of idebenone in Leber’s hereditary optic neuropathy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572931/
- S Jaber, B Polster (2015) Idebenone and neuroprotection: antioxidant, pro-oxidant, or electron carrier? https://www.ncbi.nlm.nih.gov/pubmed/25262284
- Guan et al (2016) Idebenone Maintains Survival of Mutant Myocilin Cells by Inhibiting Apoptosis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989434/
- K Lyseng-Williamson (2016) Idebenone: A Review in Leber’s Hereditary Optic Neuropathy https://www.ncbi.nlm.nih.gov/pubmed/27071925
- Yu-Wai-Man et al (2017) Evaluating the therapeutic potential of idebenone and related quinone analogues in Leber hereditary optic neuropathy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644719/
- Montenegro et al (2018) Idebenone: Novel Strategies to Improve Its Systemic and Local Efficacy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853719/
- Tiefenbach et al (2018) Idebenone and coenzyme Q10 are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177011/
- Pemp et al (2021) Changes in Visual Function and Correlations with Inner Retinal Structure in Acute and Chronic Leber’s Hereditary Optic Neuropathy Patients after Treatment with Idebenone https://pubmed.ncbi.nlm.nih.gov/33406801/
- Lee et al (2022) Idebenone Regulates Aβ and LPS-Induced Neurogliosis and Cognitive Function Through Inhibition of NLRP3 Inflammasome/IL-1β Axis Activation https://pubmed.ncbi.nlm.nih.gov/35222363/
- Yang et al (2022) Facile Solvent-Free Preparation of Antioxidant Idebenone-Loaded Nanoparticles for Efficient Wound Healing https://pubmed.ncbi.nlm.nih.gov/35335897/
- Borrelli et al (2022) Visual Outcomes and Optical Coherence Tomography Biomarkers of Vision Improvement in Patients With Leber Hereditary Optic Neuropathy Treated With Idebenone https://pubmed.ncbi.nlm.nih.gov/36375592/
5
Based on 2 Reviews
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01/29/2025
Alejandro A.
Verified Buyer
US
Good energy booster
I currently take care of my mitochondrial health by taking CoQ10 and using NIR. So far Idebenone has delivered successfully, the change, while not significant, is definitely noticeable, will be buying more soon. Plus, it\'s the only provider of it I have found.
01/29/2025
Alejandro A.
Verified Buyer
US
Good addition for mitochondrial health
Looked into it given that I wanted to find additions to my current mitochondrial regimen, which so far has had good results with CoQ10 and NIR, then, when I learned this was a synthetic equivalent of CoQ10 I went for it. Good results, given the amount of supplements I take, it takes me time to notice results through an A/B testing of sorts and I have definitely seen noticeable changes in energy levels. Super recommended, plus I have not found it anywhere else!
01/01/1970
CosmicNootropic
Dear Alejandro, thank you for sharing your experience! We're so glad to hear that this supplement has positively impacted your energy levels and fits well into your mitochondrial regimen. We appreciate your trust!
12/06/2024
Nazar
Verified Buyer
AU
don\'t bother
they have no control on their delivery company they use. you can\'t chase it. they won\'t contact the shipping company. and the shipping company only receives complains from inside USA. so if you outside USA they won\'t bother solve your problem. all they will do and say we understand your frustration and sorry.
02/28/2023
Mikias A.
Verified Buyer
US
Energy booster
Best energy booster! I take this when I am sleep deprived and it gives me focus and energy throughout the day. This really affects Mitochondria to function 2X for more ATP
01/01/1970
CosmicNootropic
Dear Mikias, we're glad that you are satisfied with the product, thank you for the feedback!
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