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ETHOXIDOL ® (Ethylmethyl-Hydroxypyridine Malate)
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Buy Ethoxidol ® (Ethylmethyl-Hydroxypyridine Malate) Online!
Ethoxidol ® (Ethylmethyl-hydroxypyridine malate) is an antioxidant that helps cells survive, reduce the harmful effects of ischemia, and restore neurological and mental activity.
| Synonyms | Emoxypine malate / Ethylmethylhydroxypyridine malate / 2-Ethyl-6-methyl-3-hydroxypyridine malate |
| Form: | 20 pills of 100mg |
| Form description: | White or off-white chewable tablets of flat-cylindrical shape with a chamfer and breaking line; “marbling”, blotches, and some surface roughness are possible. |
| Active ingredient: | Ethylmethyl-hydroxypyridine malate – 100 mg |
| Excipients: | Acetylglutamic acid (N-acetyl L-glutamic acid) – 68 mg, deanol (2-dimethylaminoethanol) – 32 mg, glycine – 20 mg, microcrystalline cellulose – 260.1 mg, povidone (collidone 90F) – 1.6 mg, lactose monohydrate (milk sugar) – 36 mg, pregelatinized starch (starch 1500) – 30 mg, colloidal silicon dioxide (aerosil) – 9.5 mg, magnesium stearate – 6 mg, croscarmellose sodium (primellose) – 12.8 mg, sodium cyclamate – 18 mg, flavor orange (food flavor “Orange”) – 6 mg. |
| СAS Number: | 1202186-30-8 |
| ATC code: | C01EB |
| Pharmacological action: | Antioxidant |
| Shelf life: | 3 years. Do not use it beyond the expiration date printed on the package. |
| Storage conditions: | Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep out of reach of children. |
| Terms of release: | Over-the-counter |
| Manufacturer: | Valenta Pharm / Sintez Pharmaceuticals |
What is Ethoxidol?
Ethoxidol ® (Ethylmethyl-hydroxypyridine malate) is a combination research material that inhibits free radical processes and has antioxidant, membrane-protective, anti-hypoxic, nootropic, anticonvulsant, anxiolytic, and stress-protective effects.
Ethoxidol contains ethyl methyl hydroxypyridine malate, which is similar to another product – Mexidol. In studies Ethoxidol was shown to be more effective than Mexidol in cardiac antiarrhythmic effects; other effects were similar. [1] It should be noted that Ethoxidol contains other active ingredients such as dimethylethanolamine (DMAE), N-Acetyl-DL-glutamic acid, and glycine.
What is Ethoxidol Used For?
Ethoxidol instructions list the following uses:
- Complex therapy for coronary heart disease;
- Complex therapy of ischemic stroke;
- Encephalopathy;
- Mild to moderate cognitive impairment.
What are Ethoxidol Benefits and Effects?
Ethoxidol is used in anti-ischemic therapy as it stimulates blood flow in the penumbra. It also reduces total cholesterol and low-density lipoproteins.
Research says that the product can increase the body’s resistance to various damaging factors and pathological conditions such as shock, hypoxia, ischemia, cerebrovascular accidents, and intoxication with alcohol and antipsychotics (neuroleptics). [2]
Certain studies indicate that Ethoxidol may imporive brain metabolism, brain blood supply, microcirculation, and blood rheological properties and reduce platelet aggregation while stabilizing membrane structures of erythrocytes and platelets that are involved in hemolysis. [3]
Is Ethoxidol Safe To Take?
Ethoxidol is generally well tolerated. In rare cases, it can cause allergic reactions, dyspeptic disorders, nausea, and dry mouth or diarrhea. The symptoms disappear on their own or upon the withdrawal of the product. Prolonged administration can cause flatulence and sleep disorders.
FAQ:
What Are Ethoxidol Contraindications?
Hypersensitivity to the components, lactose intolerance, lactose deficiency, glucose-galactose malabsorption, acute kidney injury, acute liver failure, children under 18, pregnancy and lactation.
Can I Overdose on Ethoxidol?
Overdose is unlikely due to the low toxicity of Ethoxidol. If occurred, an overdose can cause sleep disorders.
What Are Ethoxidol Drug Interactions?
Ethoxidol enhances the effect of anticonvulsant drugs (carbamazepine), antiparkinson medications (levodopa) and benzodiazepine anxiolytics. It also reduces the toxic effects of ethanol.
What Is Ethoxidol Pharmacokinetics?
After ingestion, the compound is absorbed from the gastrointestinal tract and gets distributed to the organs and tissues of the body. It stays in the blood plasma for 7–10 hours. Then Ethoxidol is extensively metabolized in the liver.
What is the Mechanism of Action of Ethoxidol?
Ethoxidol inhibits lipid peroxidation, increases the lipid-protein ratio, stabilizes the membrane fluidity, and stimulates the membrane-bound enzymes and receptors.
Where Can I Order Ethoxidol Online?
You can buy Ethoxidol online from different vendors. CosmicNootropic offers Ethoxidol in packs of 20x100mg pills. We offer worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.
What is the Difference Between Ethoxidol and Mexidol?
The main difference between Mexidol and Ethoxidol is the active substance. Both preparations are hydrolyzed in GIT, but Mexidol is hydrolyzed into succinic acid (succinate), while Ethoxidol is hydrolyzed into malic acid (malate). That's why Mexidol has a more noticeable antioxidant effect, and it also shows itself better in ischemic heart disease. While Ethoxidol is a better choice for cerebrovascular insufficiency of bloodstream. It's also better in case of heart arrhythmia: all thanks to malic acid.
What is Ethoxidol Dosage?
Oral administration, chewable tablets.
As part of the complex therapy of coronary heart disease, the dosage is 1 tablet (100 mg) 3 times a day. The treatment course starts from 2 months. Individual duration of course and dosage are prescribed by the doctor.
As part of complex therapy of mild or moderate cognitive impairment, the dosage is 1 tablet (100 mg) 3-4 times a day. Individual duration of course is prescribed by the doctor.
The product is not used for cure, mitigation, treatment, or prevention of any disease. Always consult a healthcare professional before using this product to determine if it is appropriate for you. For informational purposes, you may also refer to the official instructions provided by the manufacturer.
- V Bekhterev (2016) An experimental in vitro study of antioxidant and antiradical properties of cytoflavin, vinpocetine, actovegin and ethylmethylhydroxypyridine succinate https://www.ncbi.nlm.nih.gov/pubmed/27500876
- Kukes et al (2020) The Mechanism of Action of Ethoxidol on Oxidative Stress Indices in Heart Failure and Hypotension https://pubmed.ncbi.nlm.nih.gov/34513055/
- Bogolepova et al (2021) [The assessment of the efficacy of Ethoxidol treatment in patients with chronic cerebral ischemia] https://pubmed.ncbi.nlm.nih.gov/34693686/
- Scoromets et al (2022) [Clinical efficacy and safety of Ethoxidol in cerebrovascular diseases] https://pubmed.ncbi.nlm.nih.gov/36036403/
- Zhigacheva et al (2022) Etoxidol as a Broad Spectrum Adaptogen https://pubmed.ncbi.nlm.nih.gov/35260065/
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