ETHOXIDOL ® (Ethylmethyl-Hydroxypyridine Malate)


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Buy Ethoxidol ® (Ethylmethyl-Hydroxypyridine Malate) Online!

Ethoxidol ® (Ethylmethyl-hydroxypyridine malate) is an antioxidant medication that helps cells survive, can reduce the harmful effects of ischemia, and restore neurological and mental activity.

Buy Ethoxidol with fast US delivery 📦 Save with the volume discount 📦

Synonyms Emoxypine malate / Ethylmethylhydroxypyridine malate / 2-Ethyl-6-methyl-3-hydroxypyridine malate
Form: 20 pills of 100mg
Form description: White or off-white chewable tablets of flat-cylindrical shape with a chamfer and breaking line; “marbling”, blotches, and some surface roughness are possible.
Active ingredient: Ethylmethyl-hydroxypyridine malate – 100 mg
Excipients: Acetylglutamic acid (N-acetyl L-glutamic acid) – 68 mg, deanol (2-dimethylaminoethanol) – 32 mg, glycine – 20 mg, microcrystalline cellulose – 260.1 mg, povidone (collidone 90F) – 1.6 mg, lactose monohydrate (milk sugar) – 36 mg, pregelatinized starch (starch 1500) – 30 mg, colloidal silicon dioxide (aerosil) – 9.5 mg, magnesium stearate – 6 mg, croscarmellose sodium (primellose) – 12.8 mg, sodium cyclamate – 18 mg, flavor orange (food flavor “Orange”) – 6 mg.
СAS Number: 1202186-30-8
ATC code: C01EB
Pharmacological action: Antioxidant
Shelf life: 3 years. Do not use it beyond the expiration date printed on the package.
Storage conditions: Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep out of reach of children.
Terms of release: Over-the-counter
Manufacturer: Valenta Pharm, Russia / Sintez Pharmaceuticals, Russia


What is Ethoxidol?

Ethoxidol ® (Ethylmethyl-hydroxypyridine malate) is a combination drug that inhibits free radical processes and has antioxidant, membrane-protective, anti-hypoxic, nootropic, anticonvulsant, anxiolytic, and stress-protective effects. It contains ethyl methyl hydroxypyridine malate, which is a compound that is very closely related to another drug Mexidol. Ethoxidol was shown to be more effective than Mexidol in cardiac antiarrhythmic effects, while other effects were very similar.

What is the Mechanism of Action of Ethoxidol?

Ethoxidol inhibits lipid peroxidation, increases the lipid-protein ratio, stabilizes the membrane fluidity, and stimulates the membrane-bound enzymes and receptors.

Apart from that, it should be noted that Ethoxidol contains other active ingredients such as dimethylethanolamine (DMAE), N-Acetyl-DL-glutamic acid, and glycine.

What are the Benefits and Effects of Ethoxidol?

Ethoxidol is used in anti-ischemic therapy as it stimulates blood flow in the penumbra. It also reduces total cholesterol and low-density lipoproteins.

The drug increases the body’s resistance to various damaging factors and pathological conditions such as shock, hypoxia, ischemia, cerebrovascular accidents, and intoxication with alcohol and antipsychotics (neuroleptics).

Ethoxidol improves brain metabolism, brain blood supply, microcirculation, and blood rheological properties and reduces platelet aggregation. It stabilizes membrane structures of erythrocytes and platelets that are involved in hemolysis.

What is Ethoxidol Used For?

Ethoxidol is prescribed in the following cases:

  • As part of complex therapy of coronary heart disease;
  • As part of complex therapy of ischemic stroke;
  • Encephalopathy;
  • Mild to moderate cognitive impairment.

Where Can I Order Ethoxidol Online?

You can buy Ethoxidol online at different vendors. CosmicNootropic offers Ethoxidol in packs of 20x100mg pills. We offer fast US delivery and worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Ethoxidol and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.


Also, check out this review of the Ethoxidol on Reddit


Legal Disclaimer
This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

What is Ethoxidol Dosage, How to Use It?

Oral administration, chewable tablets.

As part of the complex therapy of coronary heart disease, the recommended dosage is 1 tablet (100 mg) 3 times a day. The dosage can be gradually increased to obtain a therapeutic effect. The maximum single dose is 200 mg, the maximum daily dose is 800 mg. The minimum recommended treatment course is 2 months. The course can be repeated upon a doctor’s prescription. Individual duration of treatment course and dosage are to be prescribed by the doctor.

As part of complex therapy of mild or moderate cognitive impairment, the recommended dosage is 1 tablet (100 mg) 3-4 times a day with no limit to the duration of treatment.

What are the Side Effects of Ethoxidol?

Ethoxidol is generally well tolerated. In rare cases, it can cause allergic reactions, dyspeptic disorders, nausea, and dry mouth or diarrhea. The symptoms disappear on their own or upon the withdrawal of the drug. Prolonged drug administration can cause flatulence and sleep disorders.


Hypersensitivity to the components of the drug, lactose intolerance, lactose deficiency, glucose-galactose malabsorption, acute kidney injury, acute liver failure, children under 18 years of age, pregnancy and lactation.


Overdose is unlikely due to the low toxicity of Ethoxidol. If occurred, an overdose can cause sleep disorders that are to be treated symptomatically.

Drug interaction

Ethoxidol enhances the effect of anticonvulsant drugs (carbamazepine), antiparkinson medication (levodopa) and benzodiazepine anxiolytics. It also reduces the toxic effects of ethanol.

Pharmacokinetic properties

After ingestion, the drug is absorbed from the gastrointestinal tract and gets distributed to the organs and tissues of the body. It stays in the blood plasma for 7–10 hours. Then Ethoxidol is extensively metabolized in the liver.

  1. V Bekhterev (2016) An experimental in vitro study of antioxidant and antiradical properties of cytoflavin, vinpocetine, actovegin and ethylmethylhydroxypyridine succinate
  2. Kukes et al (2020) The Mechanism of Action of Ethoxidol on Oxidative Stress Indices in Heart Failure and Hypotension 
  3. Bogolepova et al (2021) [The assessment of the efficacy of Ethoxidol treatment in patients with chronic cerebral ischemia] 
  4. Scoromets et al (2022) [Clinical efficacy and safety of Ethoxidol in cerebrovascular diseases]
  5. Zhigacheva et al (2022) Etoxidol as a Broad Spectrum Adaptogen

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