October 27, 2020

The other regular resident of our monthly TOP-5 products list is PICAMILON ® [Nicotinoyl-GABA]. And it’s not surprising at all!


Picamilon is one of the most popular nootropics. It can be used for treating a variety of conditions, including autism, ADHD, alcohol and drug withdrawal symptoms, and others. This compound is based on a synthetic combination of GABA and niacin, with the former being responsible for reducing neuronal excitability and the latter acting as a strong vasodilator.

Picamilon dilates blood vessels in the brain. It also has tranquilizing, psychostimulating, antiaggregant, and antioxidant effects. The drug improves the functional state of the brain due to the normalization of tissue metabolism and influence on cerebral circulation (it increases the volume and linear speed of cerebral blood flow, reduces the resistance of cerebral vessels, suppresses platelet aggregation, and improves microcirculation).

After a full treatment course, Picamilon increases physical and mental efficiency, reduces headaches, improves memory, normalizes sleep. It contributes to the reduction or disappearance of anxiety, tension, and fear. The drug also improves the condition of patients with motor and speech disorders.

Its effects are similar to those of Phenibut as both drugs reduce anxiety and improve mood. However, unlike Phenibut, Picamilon has a much stronger impact on the energy metabolism in the brain because it stimulates the consumption of oxygen and glucose by the neuronal tissue.

Picamilon has been proven to be efficient when used for:

  • Cerebrovascular insufficiency, asthenia, depressive disorders in
  • Conditions, accompanied by anxiety, fear, increased irritability, emotional lability. Asthenic conditions caused by various neuropsychic diseases.
  • As a part of the comprehensive treatment of patients with acute alcohol intoxication and chronic alcoholism (to reduce asthenic, asthenoneurotic, postpsychotic, pre-recurrent conditions, as well as alcoholic encephalopathy).
  • In complex therapy of patients with migraine (treatment and prevention), TBI (traumatic brain injury), and neuroinfection.
  • Enhancement of physical and mental endurance (for people under tense and extreme activity conditions), restoration of the physical performance in athletes, improving resistance to physical and mental stress.
  • Open-angle glaucoma (for the visual function stabilization).
  • In urological practice (in children older than 3 years and in adults with urination disorders) to improve the adaptive function of the bladder (reduces detrusor hypoxia).

Here you can find the official drug sheet that we’ve translated into English special for our customers!


Unlike its younger brother Phenibut, Picamilon was ironically synthesized in the USSR for common people and not for cosmonauts, and it is the first original domestic nootropic. The drug was synthesized in 1970 at the All-Union Scientific Research Institute of Vitamins (Moscow, USSR) by V. M. Kopelevich, L. M. Shmuylovich, and V. I. Trubnikov. It was introduced into medical practice in 1986.  Currently, the rights to the drug belong to the pharmaceutical company NPK ECHO, Moscow, Russia.


Just as we did with Cerebrolysin in the previous blog post, we tried to collect some very various reviews of real people’s use, that show the preparation from different points of view.


The rate of Picamilon on the most popular Russian feedback website is 4.4 based on 104 reviews. Here are some translations of brief reviews. Click the pic or the rate to read the full review; for more, check the Picamilon page on Otzovik (Google Translate is pretty useful!).

otzovik1 5

5 stars

A great helper for anxiety and panic disorder!

Pros: Mild, effective, no side effects, affordable price.
Cons: I haven’t discovered any.



otzovik2 15 stars

An excellent nootropic agent for the brain work, I take it every day

Pros: Dilates the blood vessels of the brain, calming effect, regulates behavior, there is no lethargy at low blood pressure, drowsiness has passed, the price.
Cons: I haven’t found any.



otzovik3 14 stars

Picamilon for myopia

Pros: Sleep has improved, performance has increased.
Cons: Side effect in the form of blood pressure surges after drug withdrawal.



otzovik4 1

5 stars

Inexpensive and good nootropic drug of Russian production

Pros: Migraine attacks are less severe and rare now. Inexpensive.
Cons: Just as other drugs, it may show some side effects.



otzovik5 14 stars

Down with the feeling of unreality and dizziness!

Pros: It helps with disorders of cerebral circulation, relieves fear and anxiety; price; no side effects (for me).
Cons: Symptoms have not completely disappeared.



A few more resources where you can check the feedback and other information about Picamilon are:

  • IRECOMMEND.RU – another really popular Russian feedback website. The rate of Picamilon is 4.5 based on 82 reviews.
  • RLSNET.RU – register of medicines of Russia, which is, in fact, Encyclopedia of Medicines and Pharmacy Products.
  • DOCTOR’S REVIEW – given by the doctor-psychotherapist of the highest category with the years of practice, Candidate of Medical Sciences, Galushchak Alexander Vasilievich. Watch the video to learn about medical indications, contraindications, side effects, dosage, and duration of treatment! Here you can find the transcript.

Legal Disclaimer

All statements on this page are for informational purposes only and have not been evaluated or approved by the US FDA.
Products mentioned on this page are not intended to diagnose, treat, cure, or prevent any disease. See more

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