Anti-Anxiety Nootropics: How to Support Nervous System?

Delve into Anti-Anxiety Nootropics Category

Anxiety, a feeling of inner tension, sleep disturbances, irritability, inadequate emotional reactions – today one can observe a significant prevalence of these disorders in the population, which may be associated with the tense rhythm of modern life, as well as a decrease in stress resistance under time pressure, and excess of information as a consequence of rapid technological progress. The frequency of these conditions is quite high and amounts, according to different authors, to 15-25%. The state of anxiety, during the progression of a particular condition, leads to significant disturbances in daily activity, professional activity, social contacts, etc. Therefore, adequate therapy of such cases including treatment with anti-anxiety nootropics, or anxiolytics, is of great social importance.


Nootropics: What are those?

For more than a quarter of a century, the so-called nootropic drugs have been used in medical practice. These substances have an effect on the main neurotransmitter systems and the metabolism of brain neurons, improve memory, have a neuroprotective effect, and increase the resistance of the central nervous system to damaging influences. In recent years, research related to the search and study of the mechanism of action of new and existing nootropic drugs has been rapidly growing. 

The term “nootropics” (Greek noos – “mind, thinking”; tropes – “aspiration”) was coined by the Belgian scientist K. Giurgea in 1972 to designate a class of drugs that have a positive effect on the higher integrative functions of the brain. The most famous drug of this group is piracetam, which, according to its chemical structure, belongs to pyrrolidones, which means that it is based on GABA (γ-aminobutyric acid) closed in a cycle.

Piracetam has been synthesized for alleviate memory disorders and improve cognitive function. Later, it was found that, like psychostimulants, it increases mental performance, but is devoid of the inherent side effects of psychostimulants such as the development of dependence, tolerance, withdrawal syndrome, etc. Currently, there are more than 10 original pyrrolidone drugs on the pharmaceutical market, which are often referred to as ‘racetams’. 

Why Choose Nootropics?

Due to the wide spectrum of therapeutic activity and extremely low toxicity, nootropics have become very widespread in various fields of medicine. Statistical studies have shown that nootropics are taken by a third of the adult population of Europe and Japan. In this connection, some authors believe that they can reasonably be attributed to the group of vital drugs [8].

The most significant mechanism of action of Nootropics, in addition to the actual nootropic effect, is the ability to stimulate metabolic processes, facilitate the restoration of brain tissue in case of damage of various origins, and increase the resistance of nerve cells to adverse factors [3]. A number of experimental and clinical studies have shown other mechanisms of action of neuroprotective agents, in particular:

  • Membrane stabilizing (regulation of the synthesis of phospholipids and proteins in nerve cells, stabilization and normalization of the structure of cell membranes),
  • Antioxidant (inhibiting the formation of free radicals and lipid peroxidation of cell membranes),
  • Antihypoxic (reducing the neurons’ need in oxygen under conditions of hypoxia),
  • Improving microcirculation in the brain by optimizing the passage of erythrocytes through the vessels of the microvasculature and inhibiting platelet aggregation. 

The result of the complex effect of nootropic drugs is an improvement in bioelectrical activity and integrative activity of the brain, which is manifested in characteristic changes in electrophysiological patterns (improved information transfer between the hemispheres, increase of wakefulness, increase in the absolute and relative power of the EEG spectrum of the cortex and hippocampus and increase in the dominant peak). Improved cortical-subcortical control, information exchange in the brain, and memory formation lead to an improvement in memory, perception, attention, and learning ability, and activation of intellectual functions.

How Can I Support My Nervous System?

anti-anxiety nootropics

It is no secret that psychological health is a key to physical well-being. In the modern world people face stress on a daily basis. We can hardly escape from it. But fortunately, it can be maintained and managed. Anti-anxiety nootropics are one way of helping oneself through difficult periods of life. 

Although initially nootropics were used mainly in the treatment of cerebral dysfunctions in elderly patients with organic brain syndrome, in recent years they have become widely used in various fields of medicine, including neurology, psychiatry, and narcology [2].

Of course, aggravated anxiety disorders represent a separate group of nosological forms, the treatment of which is in the competence of psychiatrists and it includes the use of various psychotropic drugs, mainly antidepressants and, to a lesser extent, tranquilizers. 

At the same time, the largest part of those with manifestations of anxiety and other conditions are patients with various forms of neuroses (neurasthenia), psychosomatic pathology, climacteric syndrome, elderly and senile people with symptoms of anxiety caused by age-related changes in the brain, as well as persons who have been in a state of chronic stress for a long time.

The vast majority of people of the above categories do not regard their condition as a disease and do not go to doctors, preferring to treat themselves, often with the help of alcohol or drugs inadequate in this situation, which significantly worsens their condition. 

Anti-anxiety nootropics have been extensively used in Russia and former Soviet countries for many years. They passed all three stages of clinical trials and can therefore be used for the treatment of anxiety problems such as irritability, nervousness, social anxiety, insomnia, restlessness, anger, etc.

Among all the products we would like to stress very safe OTC pharmaceuticals such as Selank and Afobazole. If it is not sufficient, somewhat stronger products can also be used — Phenibut, Picamilon, Grandaxin and Stresam. For those, who prefer natural ways of regaining internal peace, it is useful to look at herbal anti-anxiety supplements: for example, Motherwort.  

It is important to remember that neurological disorders are a complex syndrome caused by disorders of neurochemical processes in the brain. They require a consultation with a specialist before using specific medical means of correcting these changes. 

Can Taking Anxiolytics Cause Weakness, Drowsiness, and Lethargy? Can I Drive a Car While Taking Anti-Anxiety Nootropics? 

During the treatment with most anxiolytics such as Phenibut or Stresam it is recommended to take caution when driving a car or carrying out potentially dangerous activities that require increased concentration of attention and quick psychomotor reactions. 

However, some anti-anxiety nootropics as Tenoten, Selank, or Intellan are suitable for administration during the daytime. They have shown no drowsiness or adverse effect on the speed of reaction. On the contrary, apart from maintaining the emotional state they are also known to improve memory and attention and make you active and efficient throughout the day.

You can also try Anxiolytics Bundle — a sample set of most popular anxiolytics to find supplements that work best for you.



  1. Selye H (1974). Stress Without Distress.
  2. Kovalev GV (1990). Nootropic preparations.
  3. Mosolov SN (1998). Contemporary trends in the development of psychopharmacotherapy.
  4. Krasucki C, Howard R, Mann A (1999). Anxiety and its treatment in the elderly.
  5. Ekman P. (2003). Emotions Revealed: Recognizing Faces and Feelings to Improve Communication and Emotional Life.
  6. Akhapkina VI, Voronina TA (2005). The Spectrum of pharmacological effects of Phenotropil.
  7. Krasnova VV, Kholmogorova AB (2013). Social anxiety and suicidal behaviour in students.
  8. Torshin IY et al (2018). Experience with mexidol in neurological practice.
  9. Mosolov SN (2020). Problems of mental health in the situation of COVID-19 pandemic.
  10. Chukanova EI et al (2021). The efficacy of antioxidant treatment with mexidol forte in 250 patients with chronic cerebral venous insufficiency.



This article is intended for informational purposes only. All medical preparations must be taken upon the doctor’s advice and under medical supervision. 

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