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Synonyms	Revia / Vivitrol / Depade
Form:	1 pill of 50mg / 50 pills of 50mg
Form description:	Hard white gelatin capsules with dark green capsule caps and white or almost white powder inside.
Active ingredient:	– 50 mg
Excipients:	Lactose monohydrate – 98.5 mg, magnesium stearate – 1.5 mg. The composition of the capsule body: titanium dioxide, gelatin. The composition of the capsule cap: iron oxide yellow, titanium dioxide, indigo carmine dye, gelatin.
СAS Number:	16590-41-3
ATC code:	N07BB04
Pharmacological action:	Opioid receptor antagonist
Shelf life:	Do not use it beyond the expiration date printed on the package.
Storage conditions:	Store in a dry dark place at temperatures no higher than 25°C (77°F). The solution should be kept in a refrigerator. Keep out of reach of children.
Terms of release:	Over-the-counter
Manufacturer:	Mosfarma, Russia

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What is Naltrexone?

Naltrexone has been classically used as an FDA-approved drug since the 1980s in a 50 mg dose for the purpose of helping heroin, tobacco, and opium addicts, by blocking the effect of such drugs. By blocking opioid receptors, Naltrexone also blocks the reception of the opioid hormones that our brain and adrenal glands produce.

In 1985, Bernard Bihari, MD, a physician with a clinical practice in New York City, discovered the effects of a much smaller dose of Naltrexone (3 to 4.5 mg once a day) on the body’s immune system. Naltrexone, blocking endorphins, sends a false signal to the hypothalamus that “there are no endorphins” and in response, the hypothalamus increases their production. Endorphins are a natural defense of the body against viruses and infections. In people with HIV, their quantity was lower than 30% of the standard amount of healthy people.

Therefore, Bihari then began to experiment with Naltrexone doses, which, on the one hand, would increase the number of endorphins, and on the other, would not block them for a long time.

The effect began with a 1.5 mg dose and ceased to increase from doses above 4.5 mg. He found that this low-dose Naltrexone (LDN) was able to enhance a patient’s response to infection by HIV, the virus that causes AIDS. The brief blockade of opioid receptors between 2 a.m. and 4 a.m. that is caused by taking LDN at bedtime is believed to produce a prolonged up-regulation of vital elements of the immune system by causing an increase in endorphin and enkephalin production.

In the mid-1990s, Dr.Bihari found in his practice that patients with cancer (such as lymphoma or pancreatic cancer) could benefit, in some cases dramatically, from LDN. In addition, people who had an autoimmune disease (such as lupus) often showed prompt control of the disease activity while taking LDN.

In human cancer, research by Professor Ian S. Zagon of the Pennsylvania State University over many years has demonstrated inhibition of a number of different human tumors in laboratory studies by using endorphins and LDN. It is suggested that the increased endorphin and enkephalin levels, induced by LDN, work directly on the tumors’ opioid receptors and, perhaps, induce cancer cell death (apoptosis). In addition, it is believed that they act to increase natural killer cells and other healthy immune defenses against cancer.

In general, in people with diseases that are partially or largely triggered by a deficiency of endorphins (including cancer and autoimmune diseases), or are accelerated by a deficiency of endorphins (such as HIV/AIDS), restoration of the body’s normal production of endorphins is the major therapeutic action of LDN.

What is Naltrexone Used For?

* In 2012 the Norwegian documentary program, called “Our Small Country”, aired a documentary about LDN that has helped many patients with a large number of autoimmune diseases and some cancers. By 2015, LDN users in Norway had increased from a mere 300 to about 15,000 people. It has also changed many doctors’ attitude toward LDN, turning a widespread skepticism towards this unfamiliar drug into a willingness to prescribe LDN at a patient’s request.

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Check out other products from the Quit Addictions category.

 

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Legal Disclaimer
This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

FDA-approved Low Dose Naltrexone can normalize the immune system – helping those with HIV/AIDS, cancer, autoimmune diseases, and central nervous system disorders.

What is Naltrexone Dosage, How to Use It?

The therapeutic dosage range for LDN is from 1.5 mg to 4.5 mg every night. The course is usually started with 1.5 mg at bedtime. After one week the dosage is increased to 3 mg, and after another week or two – to 4.5 mg. Because of the rhythms of the body's production of master hormones, LDN is best taken between 9 pm and 3 am. Most patients take it at bedtime. The drug comes in a dosage of 50 mg per pill. To make a solution with the right concentration one pill is dissolved in 50 ml of distilled water (i.e. 1 part of water and 1 part of medication). The solution is kept in a refrigerator. Shake it up prior to use. Then pull up the necessary amount of a solution using a measuring device and plunge it into the back of your mouth. Take a small glass of water after an intake.

What are the Side Effects of Naltrexone?

LDN has virtually no side effects. Occasionally, during the first week's use of LDN, patients may complain of some difficulty with falling asleep. This rarely persists after the first week. Should it do so, the dosage can be reduced from 4.5 mg to 3 mg nightly.

Drug interaction

Naltrexone blocks the action of opioid drugs.

Note

1. LDN users who are planning to have surgery performed generally discontinue taking LDN for one or two days prior to the scheduled procedure. They then are able to restart it promptly after the surgery, when they no longer need to take narcotics regularly.
2. Those patients who are taking thyroid hormone replacement for a diagnosis of Hashimoto's thyroiditis with hypothyroidism ought to begin LDN at the lowest range (1.5 mg for an adult). Be aware that LDN may lead to a prompt decrease in the autoimmune disorder, which then may require a rapid reduction in the dose of thyroid hormone replacement in order to avoid symptoms of hyperthyroidism.
3. Full-dose Naltrexone (50 mg) carries a cautionary warning against its use in those with liver disease.
4. People who have received organ transplants and who therefore are taking immunosuppressive medication on a permanent basis are cautioned against the use of LDN.

  It is important to note that full-dose Naltrexone can potentiate a disease rather than inhibit it!